ID E2RTP3_GIAIC Unreviewed; 407 AA.
AC E2RTP3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Alcohol dehydrogenase 3 {ECO:0000313|EMBL:KAE8303284.1};
DE SubName: Full=Alcohol dehydrogenase lateral transfer candidate {ECO:0000313|EMBL:EDO78089.1};
GN ORFNames=GL50803_003593 {ECO:0000313|EMBL:KAE8303284.1}, GL50803_3593
GN {ECO:0000313|EMBL:EDO78089.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO78089.1};
RN [1] {ECO:0000313|EMBL:EDO78089.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO78089.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8303284.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8303284.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00007358}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO78089.1}.
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DR EMBL; AACB02000030; EDO78089.1; -; Genomic_DNA.
DR EMBL; AACB03000003; KAE8303284.1; -; Genomic_DNA.
DR RefSeq; XP_001705763.1; XM_001705711.1.
DR AlphaFoldDB; E2RTP3; -.
DR STRING; 184922.E2RTP3; -.
DR EnsemblProtists; EDO78089; EDO78089; GL50803_3593.
DR GeneID; 5698648; -.
DR KEGG; gla:GL50803_003593; -.
DR VEuPathDB; GiardiaDB:GL50803_3593; -.
DR HOGENOM; CLU_007207_0_4_1; -.
DR InParanoid; E2RTP3; -.
DR OMA; NLMGAGC; -.
DR Proteomes; UP000001548; Chromosome 3.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 25..377
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 407 AA; 44824 MW; 9D584E22B8D31E7F CRC64;
MGDFYEEFDI SHVVRLTHGT KKGLYLGYGA IAKFGEALDD LKPSCLGFVT SPSAYKKCGL
WDTIASELEK RGIPYLHYDK IMTNPTVEAL TEAVELFSPK YDQNFVVCSI GGGSPGDSAK
SIAVLLEHRD KTAVDLYTHT FAPDRRSKLI MVNITHGTGT ECDMFAVASI LTGNSHPYKP
CIATSVIYPD YSFDDVNGML SMNTDMIRFT TIDALNHVME GSTTTIATPY SCTLAREVVF
LVARYLPRAL ADKDDRRARY WLTYAAAIAG LCFDESCLHL THALEHTLSA YVPNLIHGQG
LALLQPAVLK HIWPKVCGYL NDLFRPILGN LKGTPDEAEQ AFRRMRAFHN KVGFSGTLAD
IGFSKADVEK LVEATWACPG MDGLIALSPA PCEKADAARI FSESFYK
//
