ID E2SFZ2_9ACTN Unreviewed; 663 AA.
AC E2SFZ2;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=NAD-binding protein {ECO:0000313|EMBL:EFQ81939.1};
GN ORFNames=HMPREF0063_12951 {ECO:0000313|EMBL:EFQ81939.1};
OS Aeromicrobium marinum DSM 15272.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=585531 {ECO:0000313|EMBL:EFQ81939.1, ECO:0000313|Proteomes:UP000003111};
RN [1] {ECO:0000313|EMBL:EFQ81939.1, ECO:0000313|Proteomes:UP000003111}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15272 {ECO:0000313|EMBL:EFQ81939.1,
RC ECO:0000313|Proteomes:UP000003111};
RA Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFQ81939.1}.
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DR EMBL; ACLF03000015; EFQ81939.1; -; Genomic_DNA.
DR RefSeq; WP_007078538.1; NZ_CM001024.1.
DR AlphaFoldDB; E2SFZ2; -.
DR STRING; 585531.HMPREF0063_12951; -.
DR eggNOG; COG0300; Bacteria.
DR eggNOG; COG3320; Bacteria.
DR HOGENOM; CLU_026975_0_0_11; -.
DR OrthoDB; 9810734at2; -.
DR Proteomes; UP000003111; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05263; MupV_like_SDR_e; 1.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR44196; DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B; 1.
DR PANTHER; PTHR44196:SF5; POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-COA-REDUCTASE ACTIVITY ACRA1; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000003111}.
FT DOMAIN 5..234
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
SQ SEQUENCE 663 AA; 71359 MW; 6C27AA9668C55604 CRC64;
MAYFVTGATG FIGRRLVAEL VSRREGDIHV LVRPGSVARL ERHAHGWGRS PRVVPVSGEL
TRPGLGVDPG WIAEHAGSID HVFHLAASYD MTAGAAENDL LNLDGTRHAL ELAEAVGAGT
FHHVSSIAVA GDFSGVFTEE MFDEGQGFPS DYHRTKHGSE ALVRASTAVP WRVYRPAVVV
GDSRTGEIDK VDGPYYFFPL VKALRSALPT WWPLAAPGLG RTNVVPVDYV ARAMDELAHR
PGLDGRAFHL VNPEPHSNLE LIDTIAQAAG APHVAASLDN RVTDALAEKL VGPLAARTVG
TDLGATLSRP LLRRLGIPPE VLPHLHLAPV FDATATLAAL EGSGIAPPPL STYAGALWDH
WEQRLDPAIG ADRATRRAVQ GRTIMITGAT SGIGRATAFR LATLGATVVL VARSAEDLEH
MVDEIRSDGG TAVAYPCDLT DLEAVDEMVK EVERDLDGVD VLVNNAGRSI RRSLRLSYDR
FHDFERTMQL NYFGAIRLVM GLAPGMAHRK RGHVVNISSI GVQTNPPRFS AYIASKAALD
GWTRVVSSEL VHRGVTFTTI HMPLVRTPMI APTRLYDAFP AISSAQAADL VLRAIRDQPH
EINTLGGTAG ELGHALAPRI AFQVLNRAYH LFPDSAAARG ADAGRSASRR QRTLASVLRG
VHW
//
