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Database: UniProt
Entry: E2ZET6_9FIRM
LinkDB: E2ZET6_9FIRM
Original site: E2ZET6_9FIRM 
ID   E2ZET6_9FIRM            Unreviewed;       551 AA.
AC   E2ZET6;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE            EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE   AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN   ORFNames=HMPREF9436_00165 {ECO:0000313|EMBL:EFQ08310.1};
OS   Faecalibacterium cf. prausnitzii KLE1255.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Faecalibacterium.
OX   NCBI_TaxID=748224 {ECO:0000313|EMBL:EFQ08310.1, ECO:0000313|Proteomes:UP000006028};
RN   [1] {ECO:0000313|EMBL:EFQ08310.1, ECO:0000313|Proteomes:UP000006028}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLE1255 {ECO:0000313|EMBL:EFQ08310.1,
RC   ECO:0000313|Proteomes:UP000006028};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=3.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000926};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFQ08310.1}.
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DR   EMBL; AECU01000016; EFQ08310.1; -; Genomic_DNA.
DR   RefSeq; WP_005937394.1; NZ_GL538228.1.
DR   AlphaFoldDB; E2ZET6; -.
DR   STRING; 748224.HMPREF9436_00165; -.
DR   eggNOG; COG0517; Bacteria.
DR   eggNOG; COG1227; Bacteria.
DR   eggNOG; COG4109; Bacteria.
DR   HOGENOM; CLU_025243_1_0_9; -.
DR   OrthoDB; 9766150at2; -.
DR   BioCyc; FCF748224-HMP:GTSS-3098-MONOMER; -.
DR   Proteomes; UP000006028; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd02205; CBS_pair_SF; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   InterPro; IPR010766; DRTGG.
DR   InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE-RELATED; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   Pfam; PF07085; DRTGG; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01131; DHHA2; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR   SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          77..133
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          255..312
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   551 AA;  61163 MW;  97FD4565EFAB366B CRC64;
     MPKAAHKVVV IGHRNPDTDS ICSAIAYAEL KNKTSDLVCE PRRAGKMNQE TEFVLKKFGV
     KPPRMCTDVN PKIRDVDYRE MPGIPGSTSL RKAWEIMRDK QIDTLPVTSP DNELEGVITV
     KDIATANMDV FDTGILAKSQ TTYRNILETL GGTMVVGRED DVCTTGHIRI GTATPEMLEN
     TVEKGDIVIL TNRYESQLCA IEKEASLLII CNGSKVGRTI QRIAEEMGVA IMSAPVDTYA
     AGKLISQCAP ISYYMTRSDI MKFTLVTPVA DVTRVMAKVR HRYFPILDED GKYCGMVSRR
     NIINLQKRRI ILVDHNEATQ AVEGFDQAEI LEIIDHHRIG SLETSGPVYF RNQPVGCTAT
     IITQMYDEND MEIPPQIAGL LLAAILSDTL VFRSPTCTPL DEALAKRLAK IAGVDIDEFA
     SEMFEAGEKL DGKTAEEVFL QDFKVFMCGD IRFGVAQGSY MTRKNLLAAE ALLQPYLEEA
     RNKQNVEDIY MLLTDVPKEE SVVISDGRYA SEVLSDGFET QPAEDGSFTL PGVVSRKKQF
     IPALMTAYQE L
//
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