ID E3CEJ3_STRPA Unreviewed; 280 AA.
AC E3CEJ3;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Oxidoreductase, aldo/keto reductase family protein {ECO:0000313|EMBL:EFQ54882.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:EFQ54882.1};
DE EC=1.1.1.283 {ECO:0000313|EMBL:EFQ54882.1};
GN Name=yvgN {ECO:0000313|EMBL:EFQ54882.1};
GN ORFNames=HMPREF9626_1596 {ECO:0000313|EMBL:EFQ54882.1};
OS Streptococcus parasanguinis F0405.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=905067 {ECO:0000313|EMBL:EFQ54882.1, ECO:0000313|Proteomes:UP000003812};
RN [1] {ECO:0000313|EMBL:EFQ54882.1, ECO:0000313|Proteomes:UP000003812}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0405 {ECO:0000313|EMBL:EFQ54882.1,
RC ECO:0000313|Proteomes:UP000003812};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFQ54882.1}.
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DR EMBL; AEKM01000011; EFQ54882.1; -; Genomic_DNA.
DR RefSeq; WP_003003989.1; NZ_AEKM01000011.1.
DR AlphaFoldDB; E3CEJ3; -.
DR Proteomes; UP000003812; Unassembled WGS sequence.
DR GO; GO:0043892; F:methylglyoxal reductase (NADPH-dependent) activity; IEA:UniProtKB-EC.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:EFQ54882.1}.
FT DOMAIN 15..264
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 49
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 107
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 74
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 280 AA; 31283 MW; D5209A1E9B30E8D5 CRC64;
MNHYRLNNGV EIPVLGFGTW KAADGEEAYQ AVLAALKAGY RHIDTAAIYQ NEESVGRAIK
DSGLAREDLF ITTKLWNTHH TYEDAQAALE ESLEKLGLDY VDLYLIHWPN PKPLRKNDAW
KKRNAEVWRA MEDMLAAGKV RAIGISNFLP HHLEALLETA RVIPAVNQIR LAPGVYQSEA
IAASRKHGIL LEAWGPFGQG ELFQNEQVKE MATKYGKTVA QLALAWSLQE GFLPLPKSVT
PERIASNLNC FDFELTADDV ELLRHLPVEA GAPDPDTKDF
//
