ID E3CUX4_9BACT Unreviewed; 584 AA.
AC E3CUX4;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:EFQ24100.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:EFQ24100.1};
GN ORFNames=Apau_1682 {ECO:0000313|EMBL:EFQ24100.1};
OS Aminomonas paucivorans DSM 12260.
OC Bacteria; Synergistota; Synergistia; Synergistales; Synergistaceae;
OC Aminomonas.
OX NCBI_TaxID=584708 {ECO:0000313|EMBL:EFQ24100.1, ECO:0000313|Proteomes:UP000005096};
RN [1] {ECO:0000313|EMBL:EFQ24100.1, ECO:0000313|Proteomes:UP000005096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12260 {ECO:0000313|EMBL:EFQ24100.1,
RC ECO:0000313|Proteomes:UP000005096};
RX PubMed=21304733;
RA Pitluck S., Yasawong M., Held B., Lapidus A., Nolan M., Copeland A.,
RA Lucas S., Del Rio T.G., Tice H., Cheng J.F., Chertkov O., Goodwin L.,
RA Tapia R., Han C., Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Pukall R., Spring S., Rohde M., Sikorski J., Goker M.,
RA Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Non-contiguous finished genome sequence of Aminomonas paucivorans type
RT strain (GLU-3).";
RL Stand. Genomic Sci. 3:285-293(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; CM001022; EFQ24100.1; -; Genomic_DNA.
DR AlphaFoldDB; E3CUX4; -.
DR STRING; 584708.Apau_1682; -.
DR PaxDb; 584708-Apau_1682; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_0; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000005096; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:EFQ24100.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005096};
KW Transferase {ECO:0000313|EMBL:EFQ24100.1}.
FT DOMAIN 59..231
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 263..570
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 584 AA; 64183 MW; AF326C5A89E550CA CRC64;
MTKGFERLSM DQRLERVRVL AVVLLLTLMG GLGYFQVLRA DRYVELASRN RLRLVRLLPP
RGVITDVNGA PLAVNVRTFD VKGYPMDLQK PENRKRVVEL FRRKGFPLDE ATLTEMVEKQ
YVAPYRAVSL ANNLTLAQVA DLVADPEFSS LLFPFPVWRR VYPAGALVSH VTGFVGEITR
EELESAADAR YQGGDGVGKT GIEAFYEGRL RGDVGEEAVE VDSRGRRLRE VSRREPARGE
DLRLTLDLGA QRVAAELMGN EKGALVVLDV QDGGVKVLYS SPTFDPNPLT WGISSREWND
LLKDPARPMM DRCVSGTYPP GSTFKAVTTI AALEENVVNN HTTVYCPGYY TLGNRTFKCW
KHSGHGSENL LEAIRDSCDV FFYQTGVWLG IERLLKWSAI LGVGSPSGID IPGEASGNLA
GPAWKKKRFR EPWYKGDTVN YSIGQGFLLM TPLQLARVYA AVANGGHLVI PHLNSRERFP
RKDLRIPQSG LRSLQRGLEE VVRSGTGKRA GAFGVTVAGK TGTAQNPHGD DHAWFVGYAP
VERPRFVAVA LVEGGGHGSS VAAPLVGKIL SYLVQHDRKG GTGP
//
