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Entry: E3EXC0_KETVY
LinkDB: E3EXC0_KETVY
Original site: E3EXC0_KETVY 
ID   E3EXC0_KETVY            Unreviewed;       468 AA.
AC   E3EXC0;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-SEP-2017, entry version 51.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADO43475.1};
GN   OrderedLocusNames=EIO_2387 {ECO:0000313|EMBL:ADO43475.1};
OS   Ketogulonicigenium vulgare (strain Y25).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Ketogulonicigenium.
OX   NCBI_TaxID=880591 {ECO:0000313|EMBL:ADO43475.1, ECO:0000313|Proteomes:UP000006871};
RN   [1] {ECO:0000313|EMBL:ADO43475.1, ECO:0000313|Proteomes:UP000006871}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y25 {ECO:0000313|EMBL:ADO43475.1,
RC   ECO:0000313|Proteomes:UP000006871};
RX   PubMed=21037005; DOI=10.1128/JB.01189-10;
RA   Xiong X.H., Han S., Wang J.H., Jiang Z.H., Chen W., Jia N., Wei H.L.,
RA   Cheng H., Yang Y.X., Zhu B., You S., He J.Y., Hou W., Chen M.X.,
RA   Yu C.J., Jiao Y.H., Zhang W.C.;
RT   "Complete genome sequence of the bacterium Ketogulonicigenium vulgare
RT   Y25.";
RL   J. Bacteriol. 193:315-316(2011).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002224; ADO43475.1; -; Genomic_DNA.
DR   RefSeq; WP_013385125.1; NC_014625.1.
DR   EnsemblBacteria; ADO43475; ADO43475; EIO_2387.
DR   KEGG; kvu:EIO_2387; -.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006871; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006871};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006871}.
FT   DOMAIN      160    290       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      376    445       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     168    175       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   468 AA;  51532 MW;  90E09D61743E7D9B CRC64;
     MTKAGWVQVQ DNLKAAVGVN NFTNWIAPLE LDSLADGVAT FSVPTNFIGN YVSTNFGELI
     LYHLNRLGIQ VQRLGFIAAA ARPSLRGGLR AATPRRVGGA ARLAEPAAPE APAAPAPAKS
     NAIPAAQLDA RYTFDRFIVG KSNELAYAAA RRVAQGGPVG FNPLFMYGGV GLGKTHLMHA
     IAHELRRQQP DLNVLYLSAE QFMYRFVSAL RDKKALDFKA MLRSVDVLMI DDVQFIAGKE
     STQEEFFHTF NALVDAQKQV IISSDRAPGE IRDINDRISS RLQAGLVVDL HPSDFTLRLG
     VLESRAKTAA AAYPHVVLEE DVLPFLAHRI SSNIRVLEGA LTRLFAFAGL VNKSISIALT
     QDCLADILRA SERKVTVEDI QRRVCEHYNI RIADMVGPRR VRAFARPRQV AMYLSKKMTS
     RSLPEIGRHF GGRDHTTIMH GVKKIEQLIS SDSQMADDLK VLKRALEA
//
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