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Database: UniProt
Entry: E3GZW7_ROTDC
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Original site: E3GZW7_ROTDC 
ID   E3GZW7_ROTDC            Unreviewed;      1229 AA.
AC   E3GZW7;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN   ECO:0000313|EMBL:ADP40937.1};
GN   OrderedLocusNames=HMPREF0733_11480 {ECO:0000313|EMBL:ADP40937.1};
OS   Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Rothia.
OX   NCBI_TaxID=762948 {ECO:0000313|EMBL:ADP40937.1, ECO:0000313|Proteomes:UP000000387};
RN   [1] {ECO:0000313|Proteomes:UP000000387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17931 / CDC X599 / XDIA
RC   {ECO:0000313|Proteomes:UP000000387};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G., Hawes A.,
RA   Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W., Liu X.,
RA   Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J., Deng J.,
RA   Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D., Johnson A.,
RA   Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A., Song B.-B.,
RA   Dinh H., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M.,
RA   Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N.,
RA   Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W.,
RA   Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J.,
RA   Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L.,
RA   Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M.,
RA   Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G.,
RA   Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M.,
RA   Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L.,
RA   Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.;
RT   "The complete genome of Rothia dentocariosa ATCC 17931.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR   EMBL; CP002280; ADP40937.1; -; Genomic_DNA.
DR   RefSeq; WP_013398674.1; NC_014643.1.
DR   AlphaFoldDB; E3GZW7; -.
DR   GeneID; 29743659; -.
DR   KEGG; rdn:HMPREF0733_11480; -.
DR   eggNOG; COG1197; Bacteria.
DR   HOGENOM; CLU_005122_2_2_11; -.
DR   OMA; WAPPCRE; -.
DR   Proteomes; UP000000387; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR   CDD; cd17991; DEXHc_TRCF; 1.
DR   Gene3D; 2.40.10.170; -; 1.
DR   Gene3D; 3.40.50.11180; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR   Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR003711; CarD-like/TRCF_RID.
DR   InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047112; RecG/Mfd.
DR   InterPro; IPR037235; TRCF-like_C_D7.
DR   InterPro; IPR005118; TRCF_C.
DR   InterPro; IPR041471; UvrB_inter.
DR   NCBIfam; TIGR00580; mfd; 1.
DR   PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR   Pfam; PF02559; CarD_TRCF_RID; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; CarD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR   SUPFAM; SSF143517; TRCF domain-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00969}.
FT   DOMAIN          686..847
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          872..1022
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1229 AA;  135199 MW;  2016D8B7666415C1 CRC64;
     MKLTGLSRLL AEQPSYRHIL EACDVPAAER PVQTLIGAVA GVQAPLIADL AVAVRRQSRT
     GKTPLTLIIT PTERQAEDTA HALHSYLPDH HIESFPAWET LPHERLSPRS DTVGKRLNVL
     RSITHLETPT PQVVIAPVRA VIQPLVAGIE NLEPVSLARG EEYSFKDVIK GLTDAAYSRV
     DLVAKRGEYA VRGGIIDVFA PTAQHPVRLE FFGDELDEIR YFSTADQRTL GQEADHPTHV
     TLLPCRELLI TPEVMGRAAR LKTDYPAASS MLEKIAGGIY VEGMESLTPL LVDKMQTLVS
     LLPEESLIIS LEPERVRARA EDLVATNEEF LAAAWDASAD AGSRAPIDLG QLRVSDSGFH
     TIAATQQESL DRNLSWWEIT ELVDSVDLLN NALDDDIPTM TVAAQAPASF TGSVEQMLHE
     VGSLVRDGWT VLALTNGRGS TDRLIELFRE SISGEDPIPA IRRETLDGGT EGALQPGVVE
     VCETPASAGF LIPEARLAVL TEGEILGRRG TYAPRGASGK KLKPRKRRNA VDPLALTPGD
     YVVHERHGIG KFIEMASRPV AGVSSKHGET PLKEYLVIEY APSKRGGAPD RLFVPSDQLD
     LISHYVGSET PTLSKMGGSD WAKTKSRARK AVKEIAADLV KLYSARQASR GHAFSEDTPW
     QRELEESFPY NETPDQLTAI HEVKADMEKE IPMDRLISGD VGFGKTEVAI RAAFKAVQDG
     KQVAVLVPTT LLAQQHFETF TERFSGFPIK IKVLSRFQKA KETRAIVEDI ASGSIDVVIG
     THRILSENVK FKDLGLVVID EEQRFGVEHK EKLKQMRTNV DVLAMSATPI PRTLEMSLTG
     IRETSTLATA PEERHPVLTF VGPRTDAQIT AAIRRELMRE GQVFFVHNRV ANIDTVAAEI
     GKLVPEARIA TAHGRMSESR LEQIIVDFWE RRFDVLVCTT IVETGLDISN ANTLIVDNAQ
     NYGLSQLHQL RGRVGRGRER AYAYFLYPTD KSLGEVAHKR LKAVATHNEL GAGLQLAMKD
     LEIRGAGNLL GGEQSGHIAG VGFDLYLRLV GEAVANFRGE QENTEAEVKV DLPVNAHIPH
     DYIDAERLRL QAYRQIASAD TEQKIAEARE ELHDRYGALP EPVENLLQVA VLRREAREAG
     IHEITAPGPK LRVVSGEPLP ESRQMRLKRV YPGSTHTQPK GLSTWLTLVP RPKTLPVGGV
     DLIDGPMLEW CSKFINSIYS ADPKALEES
//
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