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Database: UniProt
Entry: E3H320_ROTDC
LinkDB: E3H320_ROTDC
Original site: E3H320_ROTDC 
ID   E3H320_ROTDC            Unreviewed;       553 AA.
AC   E3H320;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   25-OCT-2017, entry version 55.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ADP40359.1};
GN   OrderedLocusNames=HMPREF0733_10902 {ECO:0000313|EMBL:ADP40359.1};
OS   Rothia dentocariosa (strain ATCC 17931 / CDC X599 / XDIA).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Rothia.
OX   NCBI_TaxID=762948 {ECO:0000313|EMBL:ADP40359.1, ECO:0000313|Proteomes:UP000000387};
RN   [1] {ECO:0000313|Proteomes:UP000000387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17931 / CDC X599 / XDIA
RC   {ECO:0000313|Proteomes:UP000000387};
RA   Muzny D., Qin X., Buhay C., Dugan-Rocha S., Ding Y., Chen G.,
RA   Hawes A., Holder M., Jhangiani S., Johnson A., Khan Z., Li Z., Liu W.,
RA   Liu X., Perez L., Shen H., Wang Q., Watt J., Xi L., Xin Y., Zhou J.,
RA   Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Villasana D.,
RA   Johnson A., Liu J., Liyanage D., Lorensuhewa L., Robinson T., Song A.,
RA   Song B.-B., Dinh H., Thornton R., Coyle M., Francisco L., Jackson L.,
RA   Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.,
RA   Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D.,
RA   Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R.,
RA   San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S.,
RA   Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K.,
RA   Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RT   "The complete genome of Rothia dentocariosa ATCC 17931.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002280; ADP40359.1; -; Genomic_DNA.
DR   RefSeq; WP_013398152.1; NC_014643.1.
DR   STRING; 762948.HMPREF0733_10902; -.
DR   EnsemblBacteria; ADP40359; ADP40359; HMPREF0733_10902.
DR   GeneID; 29743722; -.
DR   KEGG; rdn:HMPREF0733_10902; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; AGKEHTQ; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000387; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000387};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000387}.
FT   DOMAIN      243    371       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      455    524       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     251    258       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   553 AA;  61282 MW;  9D8EC600C7BDF6F0 CRC64;
     MNAEHTQLQE RWEQVISILQ ANPEVSQRLR GFVSLAQPQA FVGTVLLIAV PSELTRNIFQ
     SQLKAPFQQA LTTVFGPGVS EAFTIDESLA QTSQTVSPSI PQIEDDSPMP PLHEVEAELH
     TPVPPHQTAD VPVADAPTAS PVDPAIFAER PQSSSPSPTD FSEVHTPHHV DSAVPTQSIS
     SPAETEDISS PATDTHTAVS SDSGWDSSAR LNPNYTFDTF VIGQSNRFAH AAAFAVSESP
     AQAYNPLFIY GDSGLGKTHL LHAIGHYAKH LFPSLRVRYV NSEEFTNDFI NSIRDDEGSS
     FKQIYRNVDM LLIDDIQFLA GKEHTQEEFF HTFNALHNHQ KQVVITSDLP PKQLTGFAER
     MRSRFEWGLI TDVQPPELET RIAILRKKAQ SESLNVPDDV MEYIASHITA NIRELEGALI
     RVTAFASLNK QPVDVALAEV VLKDLITDAG DTEITSGQVL ATTASYFDVT LEDLRSKSRT
     RTLTNARQIA MYLLRELTDM SLPRIGQELG GRDHTTVMHA VRKVGAQMAE RRTTFNQVTD
     LTNKIKQDQR ESR
//
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