ID E3K1T0_PUCGT Unreviewed; 594 AA.
AC E3K1T0;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=GTP cyclohydrolase II {ECO:0000313|EMBL:EFP78255.2};
GN ORFNames=PGTG_04211 {ECO:0000313|EMBL:EFP78255.2};
OS Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)
OS (Black stem rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=418459 {ECO:0000313|EMBL:EFP78255.2, ECO:0000313|Proteomes:UP000008783};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CRL 75-36-700-3;
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Cuomo C., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Mauceli E., Brockman W.,
RA Young S., LaButti K., Sykes S., DeCaprio D., Crawford M., Koehrsen M.,
RA Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J.,
RA Zeng Q., Kodira C., Yandava C., Alvarado L., O'Leary S., Szabo L., Dean R.,
RA Schein J.;
RT "The Genome Sequence of Puccinia graminis f. sp. tritici Strain CRL 75-36-
RT 700-3.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRL 75-36-700-3 / race SCCL
RC {ECO:0000313|Proteomes:UP000008783};
RX PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J., Cantarel B.L.,
RA Chiu R., Coutinho P.M., Feau N., Field M., Frey P., Gelhaye E.,
RA Goldberg J., Grabherr M.G., Kodira C.D., Kohler A., Kuees U.,
RA Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E., Murat C.,
RA Pangilinan J.L., Park R., Pearson M., Quesneville H., Rouhier N.,
RA Sakthikumar S., Salamov A.A., Schmutz J., Selles B., Shapiro H.,
RA Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y., Rouze P.,
RA Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA Grigoriev I.V., Szabo L.J., Martin F.;
RT "Obligate biotrophy features unraveled by the genomic analysis of rust
RT fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC {ECO:0000256|ARBA:ARBA00008131}.
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DR EMBL; DS178269; EFP78255.2; -; Genomic_DNA.
DR RefSeq; XP_003322674.2; XM_003322626.2.
DR AlphaFoldDB; E3K1T0; -.
DR STRING; 418459.E3K1T0; -.
DR EnsemblFungi; EFP78255; EFP78255; PGTG_04211.
DR GeneID; 10542047; -.
DR KEGG; pgr:PGTG_04211; -.
DR VEuPathDB; FungiDB:PGTG_04211; -.
DR eggNOG; KOG1284; Eukaryota.
DR HOGENOM; CLU_029639_1_0_1; -.
DR InParanoid; E3K1T0; -.
DR OrthoDB; 46806at2759; -.
DR Proteomes; UP000008783; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008783}.
FT DOMAIN 145..372
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 405..542
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
FT REGION 45..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 65053 MW; 6F5DF4F8A7551101 CRC64;
MATQSETTQT TNELLQHLIA EVRCLKESQT SLELKLETLG LSFPSQYPSQ SNIKPHATGG
SSSSPTEPQR PSSDSRPLPM PLSLSPSTSR SSSKLPKRGS AFEDEGSLRE KAKFVEWMKT
EGALLGVDNQ SSDMVTKPVT IYPQRLILTT YPGQTGIIPI PLEWGADDPQ KRGPVVASRH
PQSLKLRNAI GAYSGPYCIY KALATAIGAI DPNHRPDFTN TQPPFAVAPN PSWFDPSRIV
SMDPWGHLAP QLFKSYFDSG VDIRPTVACT KAHLKLAELD ESVAQGNLLI DGKIVVKSPG
TWAEKAAQTS VESTGGKWEA LSEEERHLLT SKRAGVEVQV TKAAVEPVWN LPGVAARFGI
SEAILRRALF EDTGGMYPEL LTRSDLKTYL PPIGGLTVYI FGDPNFVSDP SKELTLRVHD
ECNGSDVFGS SICTCRPYLL YGIEEAIKCA QRGGSGVIVY FRKEGRALGE VTKYLVYNAR
KRGGDSAAFY FQRTESVAGV KDMRFQALMP DVLHWLGIKK IDVMCSMSDM KHDAIVQSGI
PILLRKDIPD HLIPSDSRVE IDAKIAAGYF SASKVVTEED LKNTVGQSWE DVDH
//
