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Database: UniProt
Entry: E3LPH3_CAERE
LinkDB: E3LPH3_CAERE
Original site: E3LPH3_CAERE 
ID   E3LPH3_CAERE            Unreviewed;      5220 AA.
AC   E3LPH3;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   07-JUN-2017, entry version 43.
DE   SubName: Full=CRE-UNC-68 protein {ECO:0000313|EMBL:EFP05547.1};
GN   Name=Cre-unc-68 {ECO:0000313|EMBL:EFP05547.1};
GN   ORFNames=CRE_27285 {ECO:0000313|EMBL:EFP05547.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN   [1] {ECO:0000313|Proteomes:UP000008281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG   Caenorhabditis remanei Sequencing Consortium;
RA   Wilson R.K.;
RT   "PCAP assembly of the Caenorhabditis remanei genome.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DS268412; EFP05547.1; -; Genomic_DNA.
DR   RefSeq; XP_003114209.1; XM_003114161.1.
DR   STRING; 31234.CRE27285; -.
DR   EnsemblMetazoa; CRE27285; CRE27285; WBGene00052257.
DR   GeneID; 9811580; -.
DR   CTD; 9811580; -.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   InParanoid; E3LPH3; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000008281; Unassembled WGS sequence.
DR   GO; GO:0031674; C:I band; IEA:EnsemblMetazoa.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0040011; P:locomotion; IEA:EnsemblMetazoa.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0033365; P:protein localization to organelle; IEA:EnsemblMetazoa.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4583   4606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4771   4788       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4834   4856       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4972   4994       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5014   5039       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5099   5118       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1032   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1475   1694       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4328   4363       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4366   4398       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4341   4352       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4376   4387       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5220 AA;  593199 MW;  E498DBF787F660B7 CRC64;
     MDFDFTDISD EDHNYVTKGD IVCLSCLTSH SKEGVQGSER VCLCTEGFGN RMCTLENVAD
     KDIPPDIAMC MLYIDNALSM RALQEMMSAE SDHVSKSASG AGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQETNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMAYN KGYMVIASFH QTLWNIQSVS SGSMRTRNMG FLFGNDVLRL FHGNDECLTI
     PENWSEHPQH NMVIYEGGAA VTQARSLWRV ELVRMKWHGA LVGWEQVFRI KHITSGRYLG
     VLDNAVQLYH KEKADFDLTA FVMCQNKDPK KQMLEEKEEE GMGTATIRYG ETNAFIQHVK
     TQLWLSYQTT EVTKKGLGKV EEKKAVALKD GHMDDCYTFF MALEEESKSA RVIRKCSSVL
     NKFLKGIDAL RELGNQSPDW TRVDLNEVLK LMEDLIEYFA QPHEEQEFED KQNHLRALRS
     RQDLFQEEGV LNMILDTIDK FSQMEALPDF AGLIGEETQI MWEQISTYLY LLVAAMIKGN
     HYNCAQFASA QRLDWLFGRL SNPQSAEGIL DVLYCVLTES PEALNMINEG HIRSVISLLE
     KVGRDPKVLD VLSSLCEGNG MAVRSSQNLI TQYLLPGKDL LLQTSMRDHV SSMMPNVMLG
     VVEGSALFRK WYFEAEVEHI ETMTKQAPYL RIGWANSVGF KPFPGSGDKW GCNGVGDDFY
     SYGFDGKSMF FGGKSRVVGH KLLEKGDVIG CSIDLTIPEI RFSVNGTYMS GTFKKFNIDG
     YFFPVMSLSA KVSCRFILGG NQGRLRYGPP TGFSAVVEAV NGELGISDCL SFGDLGKNIF
     CGPQTIFNNL EPFIPTPIDV STTQLTHHAI EKHHSYAENL HELWAMRKIE LGWSYGENRS
     ETSRKHPCLT KFELLPETEK KYNIMLALTT MKTIEALGYH LITDDPPCRL RAVRLGPNFQ
     QPNGYKPGPL DTHEITLPAE LQPLTEALAR NTHNVWAKEK IKRGWTFGLS EHVDATQKRS
     PHLVPYEQVD ERIKQANRES AAENIKALQL FGIFLEPPAH EHDEIAEKEL RARKDNTRTY
     RAEATYAVNG GKWYFEFEIL TAGFMKIGWM DIGSTPEIQL GADDRSYAFD GYLGRKWHQG
     AETYGKEWKI GDVVGCFLDL NDRTISFSLN GELLLDPSGS EMAFDNVVCG DGLVPAMTLG
     SGQRGRLNFG QQSNSLKFFT TCGLQEGYEP FCVNMYRTMP MWFAKQLPRF EDISTLKSGS
     ILEVSRFPAT GNSPPCLKIL QKVTISEGGP SEKAKMEYIR LSLPVKCNDT FVKNKDKEAI
     RRQLQDYKER SQSVVSQIRA PTIPKEFDDN KEKKGFLRSM LGSKDSHESD DDRRSRTTSK
     QPSMEGDEPP AVRRSLLELP HEERQIAEDH LRDMSDRHAE KPKKGGLLSR LRDSSNTRKK
     DSDRRKEDKA AALRQMKSNS RSFDAGSLDT STLPTGQKDV LASSEMPLSG PGRQLTIKRG
     SIKKNKKGKK GEHALEKIER EKKGSIIPPE AQMDVLQVGD GPALIALKDK VDEYYYGLRI
     FPGQDPSQVW VGWVTTQYHY YNLNFDGSQG VRKCRFSEAD HHGTTVDSVQ SQNCYMVNVS
     ELLATTPDVA NTKVSGTLIG CIIDTSIGEL SFQVGTTDTG IKFKLEPGAM LFPAAFVTPT
     ATEVVQFELG RVKFTFPLSA AMFKSCEKSL VPFCPPRLTV EQIESIYWAR VPNETLRTTA
     LKLSEVRGWS VLCNDPVRIM SVYIPEKDQS LDILEMIEMP DMLEFHRQTL NLYCKLASHG
     NHKVAHTLCQ HIDEDQIMYA IKSHYLSGPM RQGFHDLLIG LHLMSHTAAR NSMAKEYVIP
     LVPQLQIKNV LDPDSESRYP QITGQSVSML SQMASEPVKK HISREEEMKL LPPSVDFEAL
     KKHVMESLQS ATHHAVMNCR DLIGGDNTNH FEPLFKLFDQ LLVIGLINDE ELECLLRLIH
     PQAFDESYEN GTTQKGLTQL ELAEPVKLQL VSILDHLCDI QLRYRIESLV AFTEGFVGEL
     QSDQCKRYME IKQTDMPPAE AAKKTKEFRC PPKEQMFRLL MCKVKEERDP EIMEEDVDVD
     QCPMAESLQQ QLRDFCELLV AKIGNAKEGD SEEQLALIES EEGSWVDSFA RIVVKVPPPL
     QEEGMEMQKK GTQNFREIIV TMLREWAQAD FIESKDLIRC MFKLLLRQYS GIREIRDAMS
     QAYVFHERNA EDVTDFIVYL IQIRELLTVQ FEHTEEAILK RGLWKLMNNR IFFQHPDLMR
     LLSVHENVMS IMMNILTAQQ GTVEHEGDEV KEKAPIKDAS EMVVACSRFL CYFCRTSRQN
     QKAMFEHLSF LLDNATMLLA RPSLRGSVPL DVAYSSFMDN NELALALKEE ELDKVAVYLS
     RCGLQPNSEL ITKGYPDIGW DPVEGERYID FLRFCVWING ENVEENANLV IRLLIRRPEC
     LGVALKGEGQ GLFSAFKEAI ALSEDIRLLE NDSHPAMLTS GLLGENPTYP SKEIEGEDYI
     DLGAATLDFY SSLVDLLAKC APDPMAIQAG KGDSLRARAI LRSLISLDDL GQILALRFTI
     PNLAAPSIEA VRRANAVQAS HTQKAVMAHT FAMVASLASE VSNTRRSQTF TSGANLARRG
     LPCVEEVDTD DSKSSDYASV HTSFSSGNEL FVPKSEKEKA ELQLLNEKKY PIVQRRRSSR
     YNPIDNTGPL PGLLPNHKGS VLLFLDRVYG IDQQDMLFHF LEQSFLPDLR AATMMDSPRA
     LESDTALALN RYLCNSVLPL LTNHSHFFSD AEHHSALLDA TLHTVYRMNR LKSLTKNQRD
     AVSDFLVAIT RELPPAMMIK LLKKVINDIL TMNDMNVLVP LRLITLHYER CGKYYGSGNH
     YGVASEQEKR LSMLLFDAIF DTLGSRPYDP ELFGKALPCM TAIGSAISPD YTLTSGLEDV
     RNKKREEEEG AWIPRTVDVS RCEIARDLEK MTELFAEHFH DSWASRKLEK GWVHGDLYSR
     ANATHPRLKP FSLLKDFEKS FYKERCSECL RALMAWNYKF EMIDRDANDR ASAARAISGT
     SISNFSPKPI DLSSMTLEKD MVNAAEKMAE HSHLIWAKKI MNDLNSKGGF MPIPLVPWDL
     LTDFERRKDR FRASEILKFL QYHGYHVECP KDEQSQNDRM KSEGERTSVE KRFAYNLLEK
     LITYLEQASL KMKSVKPSQE LTRRNSFKRE GQDVKFFEKV VLPLMHAYFN AHKSYFLEGS
     SIVQTGTASN KEKEMVANLF CRLAALLRIK NRAFGSVAKI TVKCLQGLTQ ALDLRTLVKV
     NSDIVRTSLL TFFNNCADDL YAAVNELKDG GQYSLIRGQA LKSWNSFEFA NQMIVPVLTT
     MFAHLARNHF GTDLLLDDIQ AACYKILDSL YMVTGLSSSI SHRKSIAGES EKHRPGLGQC
     LAAFASCFPV AFLEPEFNKS NKFSVLAKSQ DQSVQVQEML QNLSTHIPHL EKLLTDLETV
     ANNNTMYSDV PNVYDVDLPL MCSYMAHWFS VGPEGKRDKD DQRASVVQTT SVSCDHINRI
     FNALLKMIRN HVGIENAPWL CRVNFFAVQI IQNVTSDPVR EFVLPIAERL RRMSEKAYKE
     EEHMRTHPDD ADEGTVAEDN ARLVRDTYAF FPILMKYTDL HRAQWLKSPT WETDGVYENV
     AVIFRIWSQS QHFKREELNY VAQFEEDAAA MGGGDMKTGK AAIAERKKKR REGQDKMKEY
     FDRNGRPIIK KDKHAASIVI ACLKRLLPVG LNVFGGRELD IVQQSKEKFI QKETEEKIRE
     FIKGLLEIPV KTDPTDKNAW QLSLYRKIGK SQMRGKDEMS QEAVIEKIFN MGQVSAILHT
     ITRTKDRRRR AHHRWKTEHP QMQLSQAWKK VVSTQRKRAV VACFRMVPLY GIPRHRGINF
     FLPAFSRLWL EEEDVGQDQL IADICSGVEE EEGPRIEIIM EEGVPIVASS EETKEKETNP
     DPLKQLIRCF QRAATSEETA ASAIHEDSLY IRFADVMAKS IHIEEEDGDD GDEGEIDQAA
     KEEQSQALRG EQAVLASRGA AIMCLMYLSA SGGEPNEMVA QTLQLGIHLL SGGNVEIQKM
     LIEYLQLKKD VRFFTSMAGL MNKCSVLNLE MFERQIKAEG LGMGAELASG DNQNLNDADF
     TCSLFRFLQL TCEGHNLEFQ NYLRTQPGHT TSVNLINCTV DYLLRLQESV MDFYWHYSSK
     EVIDEGGKEY FLRAIQVCSQ VFNTLTESIQ GPCVGNQMTL ANSRLWDAIN GFFFLFAHMM
     EKLYKNSTQL ELLREFLNLQ KDMIVLMLSM LEGNVLNGSI GKQMVDALVE SQPSVEKILK
     FSDMFLKLKD LTTSQAFQDF DTNQDGWISP KEFQRAMESQ KMYTVEDITY LMMCTDVNND
     GKVDYMEFTE RFHNPARDIG FNLAVLLVNL KEHITNDPRL EKIIEKAQTL LEYFDPFLGR
     IEIMGSSKRV EKIYFEIQES WLEQWGKQQI RDSKNSFLFN VLQDDGGDQG KLEAFINFCE
     DTIFEMQHAA AISSGDSDTK MERAIKQRDY FLQQTTASDQ ISETFKSGYN YGITAASALS
     PQNISTTMKN VTTSVRQMTW TQLLYSIVIL IIRAGLAIGW GAYLLLMTIF RFAYFLTTSS
     EEEESAKHDN AKEQTKMNHD HATFSPPIVQ DFHHSHVGVD AFGVGMNADH LNVNSLPDFV
     PPPRPETPET VLPEEEKLLN QDIPSPTSPA AASKAPSIYE SIGAPQMVQL QSEADFQQGQ
     YEPKIAESNS TKTRGSILNM LARNFKTIEK ITLYLAFFIN VILLFHRVDI SHTENQEAAS
     EGDDDEEAVE SIFITGMQFP YVEYEITGWM LAQILYWISV LHLSTSFALL VSFYQLKIPL
     ITFKREKEIA RKLMFDGCWI TEEDSEELGI VDTFMWYLDR IVISAKSFPM MYWDKFVRRK
     TRSKFKDQVD EETLTSILGE EKMSTDSSYD YRYSCWLWLG VILTNGQFLY RVGYLLCSAC
     GVFVSPFFYA FHLVDVVLSF PMLKAILQSV THNLQQLILT IMMTLVVVYL YTVIAFNFFR
     KFYVQEGEDG EEPDRKCHNM LTCFIYHFYA GVRSGGGIGD ELESPYGDDL EYPRMFYDIS
     FFFFVIIILL AIMQGLIIDA FGELRDQQES ATEKLESSCF ICDIGKETFD RMPRGFEIHT
     TKEHNFANYL FFLQHLVNKD ETEYTGQETY VREKYDNRDW DFFPVGECFV KQYEDQLLQS
//
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