ID E3M266_CAERE Unreviewed; 886 AA.
AC E3M266;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=CRE-TWK-44 protein {ECO:0000313|EMBL:EFO89934.1};
GN Name=Cre-twk-44 {ECO:0000313|EMBL:EFO89934.1};
GN ORFNames=CRE_07516 {ECO:0000313|EMBL:EFO89934.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268422; EFO89934.1; -; Genomic_DNA.
DR RefSeq; XP_003109792.1; XM_003109744.1.
DR AlphaFoldDB; E3M266; -.
DR STRING; 31234.E3M266; -.
DR EnsemblMetazoa; CRE07516.1; CRE07516.1; WBGene00058255.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_013703_0_0_1; -.
DR InParanoid; E3M266; -.
DR OMA; QIHNRLI; -.
DR OrthoDB; 5010334at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR011001; Saposin-like.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF353; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF47862; Saposin; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..886
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003175026"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 388..444
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 493..562
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 744..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 100742 MW; FDA73D2FF998491E CRC64;
MRISPLLLLF TLIIFLMKNS HFAAVNKCDF CVKVLQCVYG QLGKSVGSKR LLEHKLVGTC
KRYPEYRKTC LSMAKSNIPK IFNDLQPGTY DPVKTCTDLK VNITSGKKKQ VSFSVPDEND
PPPAVVVVDT TEMNGPASQL MNYPIVRRDT IIDENAMQHL LLHESIWSHA FKKKRKRGAS
VNRPSKLKRF VSLLQIIYDK SRVHYIVPII LLIAYSVLGG LIFWSIERPN EELMLADKRN
YIAALTDDLV EVLMQIHNRL IDFNRAYSNN TYLLMIHYRG YRKFALNQIH KSVYWYTLST
FYLTEHEMHK VVALRPKNPE QLWKRHFESN FGRIRALKNY TEQLCLRCWE LGVEGANHGW
TRYNYSLMVN QSVEEYNNSV GLGHVLTPVW TFWNAMFLAV TTYTTIGYGN ITAKTKLGKL
AAMVYAVVGI PLVLMILHKS GRLFLMGLEH MWDFILRITD SFCVGSGKQR VRNTGEDRIS
EMPLILAIGV AFGWMFLCAA IFLRFEKDWD YFKSFYFFFC SLTTIGYGDV TPTNSEDMFI
IFGLIIIGLS LVSMCINVIQ LKLEKLFEEL LLTLMEELNA DPDGTRLKAG TIGAREMWRA
WKKRREKLSN GLEKAKGARN AANKASENFV KMLPFSRKRE RQHLIAELQK KLQRKEKSTQ
TDFGYPHCEE AYTETSDVDS CITDFRHSVI SDKCNALYRS NETIWNTFSA THHLLLIPDG
PICGPSRCES RPVVAMAEAS LCSSSSVNPS SYPSSHRLSS TIPSSSPGSR TSAPSAASSA
KSAPAASPSR QPPVVDFDPS RRWTFVATNR NNQRGYPRGL VVPYMYTRPL SSTVHTTEVR
RLLAEIEARL QDCRSLATPT NSIRGTVSER SFSRSVVSDT SIPEEL
//
