ID E3M438_CAERE Unreviewed; 285 AA.
AC E3M438;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=CRE-TIG-3 protein {ECO:0000313|EMBL:EFO91331.1};
GN Name=Cre-tig-3 {ECO:0000313|EMBL:EFO91331.1};
GN ORFNames=CRE_11684 {ECO:0000313|EMBL:EFO91331.1}, FL81_07585
GN {ECO:0000313|EMBL:POM47314.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|EMBL:EFO91331.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|EMBL:EFO91331.1};
RG The Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:POM47314.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX356 {ECO:0000313|EMBL:POM47314.1};
RX PubMed=26114425; DOI=10.1371/journal.pgen.1005323;
RA Fierst J.L., Willis J.H., Thomas C.G., Wang W., Reynolds R.M.,
RA Ahearne T.E., Cutter A.D., Phillips P.C.;
RT "Reproductive Mode and the Evolution of Genome Size and Structure in
RT Caenorhabditis Nematodes.";
RL PLoS Genet. 11:e1005323-e1005323(2015).
RN [4] {ECO:0000313|EMBL:POM47314.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PX356 {ECO:0000313|EMBL:POM47314.1};
RX PubMed=26394399; DOI=10.1371/journal.pgen.1005497;
RA Fierst J.L., Willis J.H., Thomas C.G., Wang W., Reynolds R.M.,
RA Ahearne T.E., Cutter A.D., Phillips P.C.;
RT "Correction: Reproductive Mode and the Evolution of Genome Size and
RT Structure in Caenorhabditis Nematodes.";
RL PLoS Genet. 11:e1005497-e1005497(2015).
RN [5] {ECO:0000313|EMBL:POM47314.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PX356 {ECO:0000313|EMBL:POM47314.1};
RA Banno H., Chua N.-H.;
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; DS268424; EFO91331.1; -; Genomic_DNA.
DR EMBL; LFJK02000006; POM47314.1; -; Genomic_DNA.
DR RefSeq; XP_003108822.1; XM_003108774.1.
DR AlphaFoldDB; E3M438; -.
DR STRING; 31234.E3M438; -.
DR EnsemblMetazoa; CRE11684.1; CRE11684.1; WBGene00057532.
DR GeneID; 9820979; -.
DR KEGG; crq:GCK72_005849; -.
DR CTD; 9820979; -.
DR eggNOG; KOG3900; Eukaryota.
DR HOGENOM; CLU_084302_0_0_1; -.
DR OMA; TEIGWND; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13752; TGF_beta_INHB; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF284; TGF_BETA_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 173..285
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 285 AA; 32334 MW; CC8B615C93ACCE3E CRC64;
MTVERQKRQV LNALGLSSRP PEFFQRPIIP YSFRSAPKHD IYGGVLEKIT IEPIQTSWSC
TTPGAIVLDC FQYFLKSINS EIVSASIVFN LKSSNISVII YEVDELFGDL QYIHRLEIKE
ILENNSIDIS SSIQGWVKKR QIRKMIKIEI VNSVTLNVVD LQDILNSPPH FEVETFQPNT
VFSGKSDCIG CCIVPFYVNF TEIGWNDWIL SPSGFYANYC SGSCSNELDE NYQMMKLSSK
DQSMIPEPSC APNYYGSIDM IVALTFQDIR KTRIHGMRAL SCSCT
//
