ID E3MA40_CAERE Unreviewed; 687 AA.
AC E3MA40;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Phosphatidylinositol 4-kinase beta {ECO:0000256|ARBA:ARBA00039877};
GN ORFNames=CRE_17093 {ECO:0000313|EMBL:EFO96804.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00036767};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878;
CC Evidence={ECO:0000256|ARBA:ARBA00036767};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037860}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268431; EFO96804.1; -; Genomic_DNA.
DR RefSeq; XP_003106964.1; XM_003106916.1.
DR AlphaFoldDB; E3MA40; -.
DR STRING; 31234.E3MA40; -.
DR EnsemblMetazoa; CRE17093.1; CRE17093.1; WBGene00060205.
DR eggNOG; KOG0903; Eukaryota.
DR HOGENOM; CLU_002446_6_0_1; -.
DR InParanoid; E3MA40; -.
DR OMA; TEIIDVM; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0110011; P:regulation of basement membrane organization; IEA:EnsemblMetazoa.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 385..672
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 78118 MW; 69FEAE22230745FA CRC64;
MKSENDVEYT IKQPDLKDAS VPNAENAGKS TDEMITAPDD DIEKEDDGEI EIGKENSIKP
THDRQSWTIR LLSSDSFDAS MAVEYLNSIQ DKPSLTFLGN QYSTTVPHSF ISTISGKRLF
DLPEKDLDFY LPQLMYLYVT KVDAASVSHA YIEERHKNDA QFTVLCIWLL NCFTRNVPNK
YENHALMLKS LLSKTNSPGS SIESMNILSL DRLEETNWTV GSTYGKYNGN FYHSEVQSQS
TALNATLDSY EKPRYGPISS QILTNQQNFI GRLVFIGVKL TQQHLFSSKQ EKTIALQSEL
NMLNSMLPTA VWIPFDFENT IFNICVDESA VLNSKDKVPY VFFAEVVRSS PHYNNVKTPA
SLDQKMKRSQ SESILLKNKS YHDSTDPSIA VFAESWAEKK SRIRGSSRYE NHQKWDLIPV
IVKTGDDLSQ EAFAQQLLFT FKDLWQEEGV PLYLRPYKIV CIGSDAGLIE PVLDTLSLHQ
IKRHLTNLFR MNGNPATPLL KHHFENVFGP VNSETYVNAQ KNFIQSTAAY SLVSYYLQLK
DRHNGNILLD MEGHLIHIDY GFLLSSSPRN LGFETAPFKL TTEIIDVMGG IDSDMFLYFK
SLLLRGLMAA RKHHRRIVSL AEIMSSGSKM QCFRAGAETV RALEARFHVS STDEQLQQLV
DTLVEGSRDS YTTRFYDSFQ YYTNGIH
//
