ID E3MCK6_CAERE Unreviewed; 1794 AA.
AC E3MCK6;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=CRE-NCA-2 protein {ECO:0000313|EMBL:EFO98541.1};
GN Name=Cre-nca-2 {ECO:0000313|EMBL:EFO98541.1};
GN ORFNames=CRE_20293 {ECO:0000313|EMBL:EFO98541.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS268435; EFO98541.1; -; Genomic_DNA.
DR RefSeq; XP_003106015.1; XM_003105967.1.
DR STRING; 31234.E3MCK6; -.
DR EnsemblMetazoa; CRE20293.1; CRE20293.1; WBGene00061652.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_000984_0_0_1; -.
DR InParanoid; E3MCK6; -.
DR OMA; TLFIAWN; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:0040017; P:positive regulation of locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1022
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1067..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1180..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1266..1282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1294..1314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1368..1384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1405..1428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1489..1515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..363
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 417..641
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 916..1211
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1260..1526
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 776..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1689..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1794 AA; 207047 MW; CFBE85AB01CA3BEA CRC64;
MFCLSACRAA ALSTTMLTRR KSSIDGTKSE RSRRRGESIG GAFTDMINIE PTSIINKSTE
LLHERFLRDM VRAACLLSMI SLCLHTPETI KMWPPLNYII LVNDVIVTLI FIGEAAVTIN
QNGLFDNQNS YLRDRWYQFE FFLLINHILS CIIHIYELCS IWFPSLNFVY YPWLGALRSA
RPFIFLRFIR SIVRFKLPKN RIKSIMKRSS QQIQNVTIFF MFFVFSYAIM GVQLFGRLNY
HCVVNGTDPN NVTIADLAIP DTMCSQKGAG GYECPGNMVC MRLQLKPQEE GFYGQFSDFA
SSLFTVYLAA SQEGWVYVLY DCLDSLPSFL AFFYFVTLIF FLAWLVKNVF IAVITETFAE
IRVQFNEMWQ TREATSDHVY TQKLEKDEDG WKLVEVDKYN RAHSNNSLYL HTIVTSTAFQ
TVMQLMILAN AIFHATFVFY HDESDQIRKV WYYYVEVGFT ILFNTEVIIK IYAFGWKAYI
ARGQHKFDCL LCIGSSLNAI WILYETNIFT YFQVFRIARL IKASPMLEDF VYKIFGPGKK
LGGLVIFTGI LLIVTSAISL QLFCYVPKLN KFTNFAVAFM SMFQIITQEG WTDVVIEILR
ACNEQAVPFV AIYFVAYHLL VTLFVLSLFV AVILDNLEMD EELKKVKQLK AREQDTIKTT
LPMRLRIFNR FPTAPTMVTM KKVSSEFPLP KIRDSFTRQF ADEFVETSDD TIQEIGLKVR
SMLSGKGPSK ETRKTTTIRH VGQLSNKTIL TSMLTESNRN RALFSESNQH LANFTRSNTS
SKHGKSGILS ANSRSRTRGL ASLKGKNMVE GFKENGDLRP EDTARKVEKH GEIDFKALQM
KRAHAEITRN RIEEEMRENH PMFDRPLFLV GRESSLRRMC QMIAHSRHSY DQNDGQHRKH
SNKYKQFHDF LAIITYLDWA MVLVTTLSCC SMLWESPWPT TGENLIFNNF YLQIAEYIFV
LVMSFELVVK CIANGLFFTP KALVTDVGDI LTIFIYIVSC FILSFPLIVI TFQTSLIFVI
WMPNHIEINS WAQLLMICRA SRPLRVYALI PHIRRVVVEL CRGFREILLV TILLVVLMFI
FASFGVQLVG GKLASCNDPM ITTRENCTGL YDVKLFVTRM EVYGKHDNAM HPSIVVPRVW
TNPRNFNFDH IGNAMLALFE TLSYKGWNVV RDILYLRHGA WAVLFIHIYV FIGCMIGLTL
FVGVVVANYT ENRGTALLTV DQRRWHDLKA RLKMAQPLHV PPKPPESAKL RCYLYDLTTS
RWFKQLFAAL VVLNSFTLVI PWNVSEEQDR KTFLLSLTVI SAICNILFTL ECLLKMIAFT
LSGFWQSRRN RIDFIITILG INWIVFHFLF QLPAYFAGGI KEWKRLTYTY GYLVVILRFF
TIAGRKSTLK MLMLTVVMSM VRSSFIIAAM FLLVLFYANA GVVLFGMVKY GQAVGKHVNF
RNGREALVVL FRSVTGEDWN DIMHDCMRAP PFCNWHPGLS YWQTDCGNYV GAIVYFCSFY
LIITYIVLNL LVAIIMENFS LFYSSEEDAL LSYADIRNFQ LVWNMVDTEQ KRSIPVRRVK
FLLRLLKGRL EVTGEDDGLL FKHMCHEMER LHNGDDVSFH DVLNMLSYRS VDIRKNLQLE
ELLQREELEY IIEEEVAKHT IRTWLENCLK NIKARQNNTL GKMSSIGSTF AFPQSQDLLT
KGVVLTEASP DEESLQGDKG SGKKKASRGN SITEIVTEAQ KKSVKRGAEK IKERRGTLRQ
MQMGTYDELE EVEEDEDTDA EIRRSSFEYS GVDMIQMSHE KQLEDVKTWW TLCD
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