ID E3MCX6_CAERE Unreviewed; 411 AA.
AC E3MCX6;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Isopropylmalate dehydrogenase-like domain-containing protein {ECO:0000259|SMART:SM01329};
GN ORFNames=CRE_20355 {ECO:0000313|EMBL:EFO98492.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; DS268435; EFO98492.1; -; Genomic_DNA.
DR RefSeq; XP_003105966.1; XM_003105918.1.
DR AlphaFoldDB; E3MCX6; -.
DR STRING; 31234.E3MCX6; -.
DR EnsemblMetazoa; CRE20355.1; CRE20355.1; WBGene00061757.
DR eggNOG; KOG0784; Eukaryota.
DR HOGENOM; CLU_031953_0_0_1; -.
DR InParanoid; E3MCX6; -.
DR OMA; FYHRIPP; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF42; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT GAMMA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..396
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 411 AA; 45718 MW; 44C66038B6266B8D CRC64;
MSTNVLGQTL RSSKNVVQKA FVATAPSSDM LRFRSPVLQT NTTKLARYGG RHNVAVLPGD
GIGPEMIDHV ERILTAVQAP IDFEEVNLTS KEDASEDLAE AITAIKRNGV ALKVFFLLKL
FLNRKFRETS KRNSITRVLS LVTWSFVVSS ISMPMFFTVL QFRLFRADIQ YGIDMVIIRE
NTEGEYSGNE HEAVNAPHPR VVESLKVVTR EKSEQITRFA FQFAKKYGRK KVTAVHKANI
QKLGDGLFLR VATDIAKNEY PEIEFNAMIV DNASMQLVSR PQQFDVMLMP NLYGNIISNI
ACGLVGGPGL VSGMNIGDDY AVFETGTRNT GTTLAGKDLA NPTAFIRAAV DMLRFLGLQM
HADIISDSLF RTLVDKRIHT ADIGGSAKSS ELVQSVIEFI EKELEDRNYR V
//
