ID E3MHE6_CAERE Unreviewed; 1386 AA.
AC E3MHE6;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CRE_22892 {ECO:0000313|EMBL:EFP01961.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS268445; EFP01961.1; -; Genomic_DNA.
DR RefSeq; XP_003104360.1; XM_003104312.1.
DR STRING; 31234.E3MHE6; -.
DR EnsemblMetazoa; CRE22892.1; CRE22892.1; WBGene00062851.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_000384_9_9_1; -.
DR InParanoid; E3MHE6; -.
DR OMA; WANINDD; -.
DR OrthoDB; 4324047at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13975; gag-asp_proteas; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00343; ZnF_C2HC; 2.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT DOMAIN 513..691
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1072..1225
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 232..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1386 AA; 156729 MW; 7D03D35383AC51B1 CRC64;
MATVEEQLAS LTQAVAQLVQ LQTTQAQAQT NATAPATPTA PRLFDQISNR IPQFQYDPEM
EKTFDQFYSR YKDVINKDGH QLSDEEKTRI VLSKISDSDY TYYSNRILPK LPVDFNYSDT
VNKLKDTFKS TSSIFKKRQE FLRLEFDGTK LEEYTGTVLR KFTAAEFKKM TDDQVCCMVW
ISGLRDERWT DMRTKALQTM ESKPNITLLE LEGEVKRLLD IRADSMSITA PSTGINLVQK
HSQRNQRQTK HQPNPKSETA PSKPCPGCGG THWLKDCKNP RKVKCRYCKR AGHLETDCRT
KQRNQNKKGA ESTINSVVIQ AATTSGSNRI YRTVVVNDKP IKMQFDTGAD VTLFHESDWI
KLGRPQLHKP TITVRSANNQ PILVKGWFEC NVTIGKDAHV LKAHVAETKT LLGIDWMARD
QQLWNTLNGS EQINLVGSLT GSACDFLDGA REQLKRSLEN SFPQVFQPGL GKCTKMKAEI
KLKPDAKPVF RKCRPVPYAT LSAVSEELDR LTLQGVLTPV DHSSWAAPTV TVKKKNGSIR
MCADYSTGLN DSIEQHRHPL PTADSIFTSI NGGKYFTQID LAEAYLQMEL SDDSKELLCI
NTHKGLYQFN RLPFGVKSAP GIFQQLMDQL INGIEGVASY LDDVIVTGST VSEHDDRLMK
VMSRINEFGL KMKLEKCNFL MQEVRFLGFI VDKNGRRPDP EKIAAIKNMP VPKDVSQVKS
FLGLIQFYGA FVKSLFRLRP PLDALTKKDT PFRWSRACQN AFDQIKEVLQ SDLLLTHYDP
NKPIIVAADA SQYGIGAVLS HRYPDGSEKA VFHISKSLNK AQQNYSQIEK EGFALVTAVT
KFHKYLHGRS FILKTDHKPL LSIFGDKKGV PVYSANRLQR WAVILLNYHF KIEYVNTMSF
GQADALSRLI AENADSKEPE DHVIAQVELD ITDTFAQGCK QLPVNAHTIR SYSRKDTTLQ
EVYKAIQTGQ WPKSVPKNSP LWEYYNRRED PYIVQGCIMF GERILVPPTL RNRVLKMLHR
AHPGIVRMKK LARGFVYWCG MDADIQKMVQ SCDQCAAVAK GPVKTTLCSW PMPTAPWQRV
HADYAGPIHG KYYLVMVDAF SKWPEIRPTT SITTSATLKL FQHVFSQFGI PDTLVTDNGS
QFTSSAFNEF CKSQGINHIR SPPYHPQSNG QAERFVDTLK RALGKLKGEE TDDTALNIFL
QNYRSTPCDA SPNHVTPAEN FIGRRIKTFL NQLLPSSAPV SSDYNHKMED QFNRQHGSRT
KEFAPHDKVY VKSYRNLSAT TWTSGVIICR LGKTLYSVRV NDNTTWKRHA NQLRRRESPP
AAKTIPMDLI EGKNFEEPKL SQDVHTQQLS PPRATPAHHS NTVSCRRASP LQSSISPTRP
SHHGPV
//
