ID E3MUM1_CAERE Unreviewed; 1062 AA.
AC E3MUM1;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CRE_21310 {ECO:0000313|EMBL:EFP09847.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS268480; EFP09847.1; -; Genomic_DNA.
DR RefSeq; XP_003100089.1; XM_003100041.1.
DR AlphaFoldDB; E3MUM1; -.
DR STRING; 31234.E3MUM1; -.
DR EnsemblMetazoa; CRE21310.1; CRE21310.1; WBGene00060736.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_000384_9_9_1; -.
DR InParanoid; E3MUM1; -.
DR OMA; HRCHANQ; -.
DR OrthoDB; 4324047at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50878; RT_POL; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 305..320
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 382..584
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 276..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 120579 MW; C1DB32A582F6ABA1 CRC64;
MTMAKELTET LRAFREQIEA STEVNRRKLE ENKWLRESLV RATGGSEANL GGDANTAPPS
RSGYSARLMG DLARRIPKFQ FILDDPDAFR KWITRNELTI TEDGKDLTER EKVRLLLGAL
EESTFHRYVD SQRDAGDIYE IAFKDTVASL NKVFGSHRSM MIRRQECLQI SRSSGLFHDP
LEYSNKISEA VLDSKLSVMT SDDWSVFVFL RGLDSPGDAA AKAYLMQWAE QSERKKETVT
LAAIHDEWIR FIQLKQQTKT VAASSPKQQV GVNKVEKKNF RGDNKNKTET TANKSDSHSN
KEVTCFKCGE RGHTAPQCPQ NSGKKKGRYW VKKGVQKTQC VRVDGLHENQ NNVSKPTMRV
NVDGQLLSFQ VDTGIEITLI NEQSWKDIGC PELEKVPHRI SCANGTQMSV KGRALVSFEL
KGIQYTDYVY VKAKDDNLIG MSWISSLRDE HHPLPTSEHI FGKLKGSIFS QIDLRDAYLQ
LELDEEAQKL AVINTHLGLF KYRRMPFGLK PAPAVFQKVI DKLIAGIPGV AAYLDDVIVA
TDTMQEQEKI LKKLFARFQE YGFKVSLVKC TFAKSEIKFL GFIVNGEGRK PDPEKTEVIR
KMDSPKNQKQ LASFLGAICF YSRFVPKLSE LRGPLDRLMK QDVKWKWTPI EQNAFDKLKN
AVADSTMLSH FKEDWKIIVA ADANQYGIGG VLMHETPDGK EVPIAHFARS LTDTEKRYSQ
IEKEALALVY TVKKSHKFVF GRKFSLQTDH KPLSAIFGDS RDLPVHSQNR LVRWATTLLA
YNFDISYIST AKFSKADWLS RMIQNYPRDE DDVVIDLYNY GFDWSEIQRG NKSSWEFGVV
RRRFGNVLYE VQIGERFHRC HANQLRLRFG DRSKEDMFEE TVFPMFFETV KGDGVQTQLS
GGPRVHGEGL NSLQFSDTSR SVDISSDFRD SFVGEEGVGR RESGKSARPP VELNFADDYD
SMSDRRRAPE FTTTINRSPH SDTNTNPSHS LRRSQRTKRA PTRFDPCPAT SQGRGKPRGS
NRQDRPAGRG RGVAPASNRS VPLNSSLKGE GVGKERGRPR WH
//
