ID E3NBQ2_CAERE Unreviewed; 698 AA.
AC E3NBQ2;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=CRE-EGL-23 protein {ECO:0000313|EMBL:EFO92061.1};
GN Name=Cre-egl-23 {ECO:0000313|EMBL:EFO92061.1};
GN ORFNames=CRE_13085 {ECO:0000313|EMBL:EFO92061.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; DS268587; EFO92061.1; -; Genomic_DNA.
DR RefSeq; XP_003094187.1; XM_003094139.1.
DR AlphaFoldDB; E3NBQ2; -.
DR STRING; 31234.E3NBQ2; -.
DR EnsemblMetazoa; CRE13085.1; CRE13085.1; WBGene00071634.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_028432_0_0_1; -.
DR InParanoid; E3NBQ2; -.
DR OMA; DEPECEW; -.
DR OrthoDB; 2882865at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF317; PROTEIN CBR-EGL-23; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 181..242
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 321..395
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 480..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..186
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 488..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..565
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..591
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 78006 MW; 93A74DFA3B986ED2 CRC64;
MKLTLKKSVF RGEKHLLQKA TPLFVHFLMI VSVGAYAIFG ALVMRSLESK TITTIEKKTD
VHRRHLNLSS SVEIQNVPPI PSELRHRRRR RHNDTLDQFS ENFRMSREKR AAAHIMRSRK
CVISVIKKMS RLECSMDTLD EKLVKALDEC YHVAVEHNTH VNHVLYENSK EEVESVGEES
EEEIAEWSFM DSLLFAFTVI TTIGYGNVAP RTFGGRLFVI GYGLIGIPFT LLAIADLGKF
ISEMMVVAKT FCKKTWKKLK KAWNPNFIRY PKLSGAKDLS NTDIEEKILE NEKIENEIES
SETSEEEDDL TETEATSLFI LFLLYIAFGG MMLAAYEPDM DFFKAVYFNF VTLTSIGLGD
IVPRSETYML ITIVYIAIGL ALTTIAIEIA ADALKKLHYF GRKIENVGNV AIWFGGKKIT
MKALVKNLGD QFNLPTTVVK SLNLDHFVDQ AIKVEEGEIE TLRPPPFEPD SERFDAEFAD
EPESEWIRDP TPTPPPSPQP VYRLPSPKPK TPSPLPSPSI TDKSMAIATP SPEESEDDEE
LILPSPEPSP IREPTPSPPP REPTPREPTP EPEPYREPTP PPPPPPKPRP LTAAEIAAQK
RKAYSEEAWR RYQEYQKQWK KFRQTQKTPA PGASTSGAST SKQSGASPEG GGQAGTGPST
RSQSVTSVAS GKTSRSATPE SKKSSHPSSS SRRESGAK
//
