ID E3NH01_CAERE Unreviewed; 1168 AA.
AC E3NH01;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=CRE-CYK-3 protein {ECO:0000313|EMBL:EFO97531.1};
GN Name=Cre-cyk-3 {ECO:0000313|EMBL:EFO97531.1};
GN ORFNames=CRE_08569 {ECO:0000313|EMBL:EFO97531.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS268663; EFO97531.1; -; Genomic_DNA.
DR RefSeq; XP_003092311.1; XM_003092263.1.
DR AlphaFoldDB; E3NH01; -.
DR STRING; 31234.E3NH01; -.
DR EnsemblMetazoa; CRE08569.1; CRE08569.1; WBGene00055517.
DR GeneID; 9799308; -.
DR KEGG; crq:GCK72_010683; -.
DR CTD; 9799308; -.
DR eggNOG; KOG1870; Eukaryota.
DR HOGENOM; CLU_001060_10_1_1; -.
DR InParanoid; E3NH01; -.
DR OMA; HICLGLR; -.
DR OrthoDB; 5474185at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0005815; C:microtubule organizing center; IEA:EnsemblMetazoa.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR GO; GO:0030010; P:establishment of cell polarity; IEA:EnsemblMetazoa.
DR GO; GO:0009992; P:intracellular water homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0031023; P:microtubule organizing center organization; IEA:EnsemblMetazoa.
DR GO; GO:1903673; P:mitotic cleavage furrow formation; IEA:EnsemblMetazoa.
DR GO; GO:0016579; P:protein deubiquitination; IEA:EnsemblMetazoa.
DR GO; GO:1904785; P:regulation of asymmetric protein localization involved in cell fate determination; IEA:EnsemblMetazoa.
DR CDD; cd02674; Peptidase_C19R; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281}.
FT DOMAIN 176..211
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 297..411
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 569..1165
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 681..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 133514 MW; 658B046BF0256D1D CRC64;
MGNTILTGRS NAIAPIISAE DARTYISEEE YRRIRQAFQR FKNGCINYDE FCYHVLGGAQ
IPEEKRRLLF SFFSRGAESI SFDNLLSSLV GLCRVEEVQS RFIEEYHEFA SWGLSPPKLT
IPLNDSYISF YEVMSYVTHL SVNEVIELEK VFATISDRAV CKLNEDKWKQ ALGGCFPDSY
AERLFAVFDE NRDGQIDFRE LVCTLSALCR GPHPGRISQL ARIWDVDCDK LLSDEELSNM
YKDLEVPVEH QTVTKSANGK AALIDFGIWA QENEKYISEY YSMALQIGHI CLGLRPESRK
MELQIVNEFE ARASILPLTE WNIVSSGWHS EFRTLLEADK SPMPIDNSGI KGTREDSWTS
RVACISAESA RLKPDLVPSD YIRVPVPLWR AWLRWHGCAL TVDSQFTRKY LDGEFFEDNK
PALELYPLEI LLLGHDRKKS HDGSETTPRS LTPWACAQVS RSMTVDELLS LCKTELRLGD
GDARLWQVVK ENEEGNVLLD DGNQNLHQLY TSLGKTKKVN KMKLLLEVRE RGTGVWPEEL
RASLTGKQIT AASTLSSSNA QLSGRPGAVG LVNYGNFCYR NAGIQCLARV SPLTQYFLED
EHLEDIKKAN TRRKDAIETT IEYAKLLREM WAAKKKNIAP NDFNDAIRMN SDMFECSEQH
DCQEFVAFLL DQLHTSMYEA NKTLHPPPPD EDKKEVTRDL KDETDEEKAE RSWTEYEKQN
DSLVTELFTG QLRSRLICRT CQSSSSVFEP FTSLSLPIGF EDVDLYQVIV VHRDGRIPRR
YGFRLSRDSK IGHLREVVAA SSGISMSHIT IQCMSSKGTL MSRSPNHKSS NLRDEYPLSS
FPSGARLYAL ELPESTGENE WRVAMHRKLQ YNHEPHILGS TAGFIVSRFG LPLIVGLDEH
VTGKKLYEDV MYQMHRFMEH SVNSFSSRAH DPCEDDASGF PFTLCLVDQN YEWCGQCPAL
RFCRGCPIRP DEGKVFIPAN CPIAVDWLPI ALYLRYNHSQ EQACEDDPSV AETWSRHFAP
SSLEHCIEKF SCPETLDAAI QCDRCEKKTM RDKVMTIWKL PKYLIIHLKR FEFLREQGRM
GKCKRTVNFP LKHFDPAPFV DKPDGNTYEC IALANHYGQL SCGHFIAYAK SNEDKWLLLN
DCSVREVSEE EVDKQGAYLL FYERKDVK
//
