ID E3NI16_CAERE Unreviewed; 266 AA.
AC E3NI16;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=CRE_27895 {ECO:0000313|EMBL:EFO98723.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|Proteomes:UP000008281};
RN [1] {ECO:0000313|Proteomes:UP000008281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB4641 {ECO:0000313|Proteomes:UP000008281};
RG Caenorhabditis remanei Sequencing Consortium;
RA Wilson R.K.;
RT "PCAP assembly of the Caenorhabditis remanei genome.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DS268691; EFO98723.1; -; Genomic_DNA.
DR RefSeq; XP_003091956.1; XM_003091908.1.
DR AlphaFoldDB; E3NI16; -.
DR STRING; 31234.E3NI16; -.
DR EnsemblMetazoa; CRE27895.1; CRE27895.1; WBGene00072144.
DR eggNOG; KOG1218; Eukaryota.
DR HOGENOM; CLU_077229_0_0_1; -.
DR InParanoid; E3NI16; -.
DR OrthoDB; 2880096at2759; -.
DR Proteomes; UP000008281; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0001708; P:cell fate specification; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR039178; Lag2.
DR PANTHER; PTHR22669:SF10; DELTA-LIKE PROTEIN; 1.
DR PANTHER; PTHR22669; DELTA/SERRATE/LAG-2 DOMAIN PROTEIN; 1.
DR Pfam; PF01414; DSL; 1.
DR SMART; SM00051; DSL; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW ECO:0000256|RuleBase:RU280815}; Membrane {ECO:0000256|RuleBase:RU280815};
KW Reference proteome {ECO:0000313|Proteomes:UP000008281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..266
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003178615"
FT DOMAIN 123..167
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 172..210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 125..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 138..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 158..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 200..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 266 AA; 29773 MW; 52AD49C7E9407E4E CRC64;
MNHYYSLHFG IFFLVFNQVK CTGYLEVSFK SDFNLKSVLN VSSLNTNSSN SRLVPFLVSP
NKTEKLSRIP IDFNETVIIT VFVINQDRLD IDNATITATF TPRRGILSPL TVMYPFTGIK
INIGCDTQYY GDQCNVFCCS ETASRVGKEC NSLGQLGCPV DKKGLDCKQP ISKKWCKCKN
KGSCISSFGK NLHERIQCSC PVGFTGIQCE KEVPSVEMMS VYGVDPKKFE IGTAKMLYES
VVDNEMVEVT RPHSSHLLHN LKINDA
//
