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Database: UniProt
Entry: E3P3R5_SIV
LinkDB: E3P3R5_SIV
Original site: E3P3R5_SIV 
ID   E3P3R5_SIV              Unreviewed;       380 AA.
AC   E3P3R5;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Pol protein {ECO:0000313|EMBL:ACR21892.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ACR21892.1};
OS   Simian immunodeficiency virus (SIV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11723 {ECO:0000313|EMBL:ACR21892.1};
OH   NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:ACR21892.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SmmFGb {ECO:0000313|EMBL:ACR21892.1};
RA   Novembre F.J., Reeve A.B., Patel K., Pearce N.C., Augustus K.V.,
RA   Domingues H.G., O'Neil S.P.;
RT   "Neuropathogenic SIVsmmFGb Genetic Diversity and Selection-Induced Tissue-
RT   Specific Compartmentalization During Asymptomatic Infection and Temporal
RT   Evolution of Viral Genes in Lymphoid and Central Nervous System Tissues.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FJ399303; ACR21892.1; -; Genomic_DNA.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR   Pfam; PF00552; IN_DBD_C; 1.
DR   Pfam; PF02022; Integrase_Zn; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR   SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50876; ZF_INTEGRASE; 1.
PE   4: Predicted;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00450}.
FT   DOMAIN          1..93
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   DOMAIN          99..140
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50876"
FT   DOMAIN          149..300
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          319..366
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51027"
FT   DNA_BIND        319..366
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACR21892.1"
FT   NON_TER         380
FT                   /evidence="ECO:0000313|EMBL:ACR21892.1"
SQ   SEQUENCE   380 AA;  42542 MW;  EAF2A27EB1F9ABD0 CRC64;
     KAKPLEQTTN QQAELGAFYL ALADSGPKAN IIVDSQYVMG IIAGQPTESE SRLVNQIIEE
     MIKKGAIYVA WVPAHKGIGG NQEVDHLVSQ GIRQVLFLEK IEPAQEEHEK YHSNVKELVF
     KFGIPRLVAK QIVDACNKCH QKGEAIHGQV NAELGTWQMD CTHLEGKIII VAVHVASGLI
     EVEVIPQETG RQTALFLLKL ASRWPITHLH TDNGANFTSQ EVKMVAWWAG IEQTFGVPYN
     PQSQGVVEAM NHHLKTQIDR IREQANSIET IVLMAVHCMD FKRRGGIGDM TPAERLVNMI
     TTEQEIQFQQ SKNSKFKNFR VYYREGRDQL WKGPGELLWK GEGAVILKVG TEIKVVPRRK
     AKIIKDYGGG KELDSGSHLE
//
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