ID E3S001_PYRTT Unreviewed; 1726 AA.
AC E3S001;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTT_15336 {ECO:0000313|EMBL:EFQ88689.1};
OS Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus)
OS (Drechslera teres f. teres).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=861557 {ECO:0000313|Proteomes:UP000001067};
RN [1] {ECO:0000313|EMBL:EFQ88689.1, ECO:0000313|Proteomes:UP000001067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0-1 {ECO:0000313|EMBL:EFQ88689.1,
RC ECO:0000313|Proteomes:UP000001067};
RX PubMed=21067574; DOI=10.1186/gb-2010-11-11-r109;
RA Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S.,
RA Oliver R.P., Friesen T.L.;
RT "A first genome assembly of the barley fungal pathogen Pyrenophora teres f.
RT teres.";
RL Genome Biol. 11:R109.1-R109.14(2010).
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DR EMBL; GL536242; EFQ88689.1; -; Genomic_DNA.
DR RefSeq; XP_003303206.1; XM_003303158.1.
DR STRING; 861557.E3S001; -.
DR EnsemblFungi; EFQ88689; EFQ88689; PTT_15336.
DR KEGG; pte:PTT_15336; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_001471_0_0_1; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000001067; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001067}.
FT DOMAIN 363..487
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1478..1722
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..191
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1726 AA; 191293 MW; 3815A3097E9133DF CRC64;
MALPAQQQNA FAAPGSPAEA KRHFLPPSAG ADTARRRADD SRRLRRVKDS KEQLKRRTTR
ARGASYSTID TTASNTSAGR SYTVANVNNG VIYLRPVVRP GNLRPLPQPH PFVLPPQTPP
DSATLDSLRP LSDEWEQSLY GSRTPRSEPT PPLPDVNEQA DALRPHAHPH PYPHPYTHSH
PHSHSHSHSH GRSRSFSTAE DHHHHHHHHH HHHHPSSPTE PGTFKVVIER PSHGRPKTAD
TSSFPLLQVP IPHYRLGTPR FSTRGTADLR SSVYTRASGG GVDDFANSLL TPQRGARQSF
LSSRPLSEAY SPVPHRFRAT MDRPPIALSG PSSARISQAP IGPRLYDALT ANPDDRAVVR
FNVHGDMIAA TPARLVAHIT SPSFLDYELL SDFFLTFRAF LSTRDLIAYL ISRLRWAVER
QDDFGRIVRV RTFVALRHWI LNYFVDDFMP CYALRCNFCD LVNSLYTDLQ AREDGGGGDL
KIVGELKKCW RRTCALYWDT EDSFAQNCPD TELLPGGEET RPGPVEEPVP ILLRPTTPPP
RSTVRDTKET MGSNPSDHFA SRHMDWAQRA RHTPQNSMGS PHVPSQDYEN ETGHQVPLSP
ASTQSMHVLS CSIPMRSTNR QDNAVELPLY PHPVPVPIAN PTPANTVRLT SSPQQPSSPK
RNHRPAHSHS HSHTHTRSGS FSDALRDSRA PLSIHKSTLA DYAMSAVTNM PGTLVRGGLI
HPGSPYFQVK TLRPVRSQHL QESDDADVSD SQRLGYGSSP GMKKIFGSVR RALSTRQQSS
ASPQLGGIAP QRQPPGMRAS NPGAASTVSV SGGIQKRRIV RPTPQVRIDI LAATVAESFQ
AAVQEQLAHE SQENNGVEPP DLGGFEFEFD ENGAPTSKNV QKQNRNPDPR VHSTITTGSK
SIVIIDDTGA PPPPPLPVAA TLSTDLGRLA AQPQSHRRGV SIDERLMGEN TNSVQHYDLY
NDSEPQRRLS EEQDTSQVSV RRPMLRRSMS AGPEGMHSFR HRGSPKASFA RGSSLRRHAS
YNSVLSRHQG SPSIATFQTM SSDNDPFFLD RQPLTEASGP ARQLRRRPGG DLRAADNIHD
LEILQRPHST GSVSNRTHSV SNSVILRSDR YIDPEAFRSV EGPPEAEVPK KPISLVATHS
SQPNLRPSFE AEVAKLAALP DDTDDEGGVE SALMKLEGRY EKKSPNTNSR RTTVDMDEPL
PTTMIEQIFR PDTAEQDQHY DNDEGFHHQL ASSETDGDGM YQLPDENGNR RAPAVTSVGE
STDSYSSIPL LDRGLSDLVT PQRARTLETM TSSAKPSPLQ FASQFPSISP QSDMPPGTSS
SMNSSIEYVV ETESMKRIPT GGTLPMTSYA RESFLLDEDE DLSDAASTPG ARSGYSSHGV
RSFFDDEVAT PGVDADNHPT HPMRHPPTPP LTANRLNDGL PDATDFDRGP PTPGLTPTAS
RCQTQTHDYA TGIPFDPPKT QPTPQLPTKH LPFVLAYDSE TLAQQFTIVE KDALDEIDWK
ELIELRWKQS SPQIRDWVQY LRTEEARGVD VVIARFNLVV KWVVSECLLT EDIHERARCI
VKYIHIATHA RRYRNYATMY QIAIALISND VSSLKKTWAL VPAAEILVMQ ELEGLVQPLK
NFHNLRLEME TATVEDGCIP FIGVYTRDLI YNAQKPAFID APVVDGERLV NFDRHHTAAS
IVKNLLRLLE ASSKYTFKVE PHIISKCLWL AALSDEEITQ RSRQCE
//
