ID E3T9P3_SPHPU Unreviewed; 265 AA.
AC E3T9P3;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE Flags: Fragment;
GN Name=VCPIP1 {ECO:0000313|EMBL:ADO30318.1};
OS Sphenodon punctatus (Tuatara) (Hatteria punctata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Sphenodontia; Sphenodontidae; Sphenodon.
OX NCBI_TaxID=8508 {ECO:0000313|EMBL:ADO30318.1};
RN [1] {ECO:0000313|EMBL:ADO30318.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20930035; DOI=10.1093/sysbio/syq048;
RA Wiens J.J., Kuczynski C.A., Townsend T., Reeder T.W., Mulcahy D.G.,
RA Sites J.W.Jr.;
RT "Combining phylogenomics and fossils in higher-level squamate reptile
RT phylogeny: molecular data change the placement of fossil taxa.";
RL Syst. Biol. 59:674-688(2010).
RN [2] {ECO:0000313|EMBL:ADO30318.1}
RP NUCLEOTIDE SEQUENCE.
RA Wiens J.W., Kuczynski C.A., Townsend T., Reeder T.W., Mulcahy D.G.,
RA Sites J.W.Jr.;
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; GU456182; ADO30318.1; -; Genomic_DNA.
DR AlphaFoldDB; E3T9P3; -.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd22769; OTU_VCIP135; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR039087; VCPIP1.
DR InterPro; IPR045827; VCPIP1_N.
DR PANTHER; PTHR14843; DEUBIQUITINATING PROTEIN VCIP135; 1.
DR PANTHER; PTHR14843:SF2; DEUBIQUITINATING PROTEIN VCPIP1; 1.
DR Pfam; PF02338; OTU; 1.
DR Pfam; PF19437; VCIP135_N; 1.
DR PROSITE; PS50802; OTU; 1.
PE 4: Predicted;
FT DOMAIN 59..212
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADO30318.1"
FT NON_TER 265
FT /evidence="ECO:0000313|EMBL:ADO30318.1"
SQ SEQUENCE 265 AA; 29602 MW; 85D21F4AE3C7AADC CRC64;
TEMNQGDVFD CSLLGDRAFL IEPEHVDTVG YGKDRSGSLL YLHDTLEDIK KTNSSQECLI
PVHVDGDGHC LVHAVSRALV GRELFWHALR ENLKKHFMEN LNHYKALFHD FIDAAEWEDI
ISECDPSFVP PEGVPLGLRN IHIFGLANVL HRPIILLDSL SGMRSSGDYS GTFLPGLIPE
EKCMGKDGML NKPICIAWSS SGRNHYIPLV GIKGATLPKL PMKLIPKAWG VPQDLIKKYI
KLEEDGCCVI GGDRSLQDKY LMRLV
//
