ID E3T9X9_CELEN Unreviewed; 223 AA.
AC E3T9X9;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ADO29955.1};
OS Celestus enneagrammus (Huaxteca lesser galliwasp) (Diploglossus
OS enneagrammus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Diploglossidae; Celestus.
OX NCBI_TaxID=102180 {ECO:0000313|EMBL:ADO29955.1};
RN [1] {ECO:0000313|EMBL:ADO29955.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20930035; DOI=10.1093/sysbio/syq048;
RA Wiens J.J., Kuczynski C.A., Townsend T., Reeder T.W., Mulcahy D.G.,
RA Sites J.W.Jr.;
RT "Combining phylogenomics and fossils in higher-level squamate reptile
RT phylogeny: molecular data change the placement of fossil taxa.";
RL Syst. Biol. 59:674-688(2010).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; GU457853; ADO29955.1; -; Genomic_DNA.
DR AlphaFoldDB; E3T9X9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 119..223
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADO29955.1"
FT NON_TER 223
FT /evidence="ECO:0000313|EMBL:ADO29955.1"
SQ SEQUENCE 223 AA; 25126 MW; A28252C8F0593644 CRC64;
SCMKAAPMKE VSLRGQGSLA YPGLRTQGNL ENLGGPNEAT RGLTSLADTF EQIIEELLDE
QEVLQPSKEN KDADLYSSRV MLSSQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR
RGELSVCDST SEWVTAAEKK TAVDMSGATV TVLEKVPVSK GQLKQYFYET KCNSKGYTKE
GCRGIDKRYW NSQCRTTQSY VRALTMDNKK RVGWRFIRID TSC
//
