ID   E3TBY6_ICTFU            Unreviewed;       289 AA.
AC   E3TBY6;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   22-FEB-2023, entry version 34.
DE   RecName: Full=Transcription initiation factor IIE subunit beta {ECO:0000256|PIRNR:PIRNR016398};
GN   Name=T2EB {ECO:0000313|EMBL:ADO27822.1};
OS   Ictalurus furcatus (Blue catfish) (Pimelodus furcatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=66913 {ECO:0000313|EMBL:ADO27822.1};
RN   [1] {ECO:0000313|EMBL:ADO27822.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA   Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA   Liu S., Kucuktas H., Ke C., Liu Z.;
RT   "Identification and characterization of full-length cDNAs in channel
RT   catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL   PLoS ONE 5:E11546-E11546(2010).
CC   -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates the
CC       RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase
CC       activities of TFIIH. Both TFIIH and TFIIE are required for promoter
CC       clearance by RNA polymerase. {ECO:0000256|ARBA:ARBA00025581,
CC       ECO:0000256|PIRNR:PIRNR016398}.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC       {ECO:0000256|PIRNR:PIRNR016398}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR016398}.
CC   -!- SIMILARITY: Belongs to the TFIIE beta subunit family.
CC       {ECO:0000256|PIRNR:PIRNR016398}.
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DR   EMBL; GU587864; ADO27822.1; -; mRNA.
DR   AlphaFoldDB; E3TBY6; -.
DR   GO; GO:0005673; C:transcription factor TFIIE complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR   CDD; cd07977; TFIIE_beta_winged_helix; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR040501; TFA2_Winged_2.
DR   InterPro; IPR016656; TFIIE-bsu.
DR   InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12716:SF8; TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA; 1.
DR   PANTHER; PTHR12716; TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT; 1.
DR   Pfam; PF18121; TFA2_Winged_2; 1.
DR   Pfam; PF02186; TFIIE_beta; 1.
DR   PIRSF; PIRSF016398; TFIIE-beta; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51351; TFIIE_BETA_C; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016398};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016398};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR016398};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR016398}.
FT   DOMAIN          54..143
FT                   /note="TFIIE beta"
FT                   /evidence="ECO:0000259|PROSITE:PS51351"
FT   REGION          11..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..270
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  32745 MW;  306BE8372BA84B74 CRC64;
     MDPALLRERE LFKKRALSTP AVEKRPASSE ASGSSKKKKS KPDKDSSSKN NADSSNGSFN
     LKALSGSSGY KFGVLARIVN YMKTRHQRGD THPLTLEEIL DETKLLDIGL KQKQWLMTEA
     LASNPKIDVR EGKYAFKPKY HLKDKKALLR LLDKHDQQGL GGVLLDDVEE GLPNAAKAIK
     ALGDQIIFVA RPDKKKILFY NDKHCHFEVD EEFQKLWRSV PVDSIDDEKI EEYLKRQGIS
     SMQDTGPKKM TPVQKRKKSG TQKKRRFKTH NDHLNGVLED YTDGVPSKK
//