ID E3TE32_ICTPU Unreviewed; 267 AA.
AC E3TE32;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=pancreatic elastase II {ECO:0000256|ARBA:ARBA00038991};
DE EC=3.4.21.71 {ECO:0000256|ARBA:ARBA00038991};
GN Name=CEL2A {ECO:0000313|EMBL:ADO28568.1};
GN Synonyms=cel2a {ECO:0000313|RefSeq:NP_001188117.1}, ela2l
GN {ECO:0000313|RefSeq:NP_001188117.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:ADO28568.1};
RN [1] {ECO:0000313|EMBL:ADO28568.1, ECO:0000313|RefSeq:NP_001188117.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA Liu S., Kucuktas H., Ke C., Liu Z.;
RT "Identification and characterization of full-length cDNAs in channel
RT catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL PLoS ONE 5:E11546-E11546(2010).
RN [2] {ECO:0000313|RefSeq:NP_001188117.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [3] {ECO:0000313|RefSeq:NP_001188117.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27307075;
RA Zeng Q., Liu S., Yao J., Zhang Y., Yuan Z., Jiang C., Chen A., Fu Q.,
RA Su B., Dunham R., Liu Z.;
RT "Transcriptome Display During Testicular Differentiation of Channel Catfish
RT (Ictalurus punctatus) as Revealed by RNA-Seq Analysis.";
RL Biol. Reprod. 95:19-19(2016).
RN [4] {ECO:0000313|RefSeq:NP_001188117.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa.
CC Hydrolyzes elastin.; EC=3.4.21.71;
CC Evidence={ECO:0000256|ARBA:ARBA00036026};
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DR EMBL; GU588612; ADO28568.1; -; mRNA.
DR RefSeq; NP_001188117.1; NM_001201188.1.
DR STRING; 7998.ENSIPUP00000004201; -.
DR MEROPS; S01.157; -.
DR GeneID; 100528918; -.
DR KEGG; ipu:100528918; -.
DR CTD; 334304; -.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000221080; Chromosome 5.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24257; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR24257:SF19; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 2B; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:ADO28568.1};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001188117.1}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..267
FT /note="pancreatic elastase II"
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001188117.1"
FT /id="PRO_5011323952"
FT DOMAIN 29..265
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 267 AA; 28946 MW; FBD5864616C86EA3 CRC64;
MMKFLVLAVL VVGAYGCGLP TFPPIVKRVV GKEDVRPHSW PWQISLQYTS SGNWYHTCGG
TLISDQWVLT AAHCISKSRT YRVYLGKHNL KSDEDGSVAI PASKIIVHEK WNSFLIRNDI
ALVKLDTPVP FSENITPACL PEDGYILAHD APCYVTGWGR MKTGGPIADI LQQALLPVVD
YATCTKSDWW GTQVKDTMVC AGGDGIVTGC NGDSGGPLNC QNADGAWEVH GIVSFGSGLS
CNYPKKPTVF TQVSSYTSWI STTIASN
//
