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Database: UniProt
Entry: E3TFN2_ICTPU
LinkDB: E3TFN2_ICTPU
Original site: E3TFN2_ICTPU 
ID   E3TFN2_ICTPU            Unreviewed;       296 AA.
AC   E3TFN2;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00011981};
DE            EC=1.3.1.48 {ECO:0000256|ARBA:ARBA00011981};
DE   AltName: Full=15-oxoprostaglandin 13-reductase {ECO:0000256|ARBA:ARBA00033119};
GN   Name=PTGR2 {ECO:0000313|EMBL:ADO29118.1};
GN   Synonyms=ptgr2 {ECO:0000313|RefSeq:NP_001187784.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:ADO29118.1};
RN   [1] {ECO:0000313|EMBL:ADO29118.1, ECO:0000313|RefSeq:NP_001187784.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20634964; DOI=10.1371/journal.pone.0011546;
RA   Chen F., Lee Y., Jiang Y., Wang S., Peatman E., Abernathy J., Liu H.,
RA   Liu S., Kucuktas H., Ke C., Liu Z.;
RT   "Identification and characterization of full-length cDNAs in channel
RT   catfish (Ictalurus punctatus) and blue catfish (Ictalurus furcatus).";
RL   PLoS ONE 5:E11546-E11546(2010).
RN   [2] {ECO:0000313|RefSeq:NP_001187784.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin
CC         F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:50588, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133374,
CC         ChEBI:CHEBI:133409; Evidence={ECO:0000256|ARBA:ARBA00023548};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50590;
CC         Evidence={ECO:0000256|ARBA:ARBA00023548};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-
CC         oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:50584,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:133408;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50586;
CC         Evidence={ECO:0000256|ARBA:ARBA00023544};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-
CC         oxoprostaglandin F1alpha + H(+) + NADPH; Xref=Rhea:RHEA:50592,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:79072, ChEBI:CHEBI:133411;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:50594;
CC         Evidence={ECO:0000256|ARBA:ARBA00023543};
CC   -!- SIMILARITY: Belongs to the NADP-dependent oxidoreductase L4BD family.
CC       {ECO:0000256|ARBA:ARBA00010460}.
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DR   EMBL; GU589166; ADO29118.1; -; mRNA.
DR   RefSeq; NP_001187784.1; NM_001200855.1.
DR   GeneID; 100528585; -.
DR   KEGG; ipu:100528585; -.
DR   CTD; 145482; -.
DR   OrthoDB; 179761at2759; -.
DR   Proteomes; UP000221080; Chromosome 9.
DR   GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF5; PROSTAGLANDIN REDUCTASE 2; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   2: Evidence at transcript level;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          1..66
FT                   /note="Oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16884"
FT   DOMAIN          117..213
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   296 AA;  31675 MW;  FE9F7F93B4770243 CRC64;
     MRCRMNDDTG ADYLLPWRLE ECIDGGGVGV VEASRSAQLA IGDSVTSFNW HWQTHDVIHG
     DCVQKVDPRM VDGHLSHVLG AVGMPGLTAL LGVREKGHVT SGAGQTMVIS GASGACGSLA
     GQIGRLDGCE RVVGICGSDE KCQTLVSHLG FTAAVNYKKG DISRALKDSC PNGVGIYFDN
     VGGPISDTVI SQMNSGSHVI LCGQISQYNK DVPYPPPLSE KTLEALRCKN ITRDRFMVLN
     YMDKHKEGLE LLSQWVKTGQ IKVLETVANG IENMGVAFCS MMTGGNFGKQ VVKISD
//
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