ID   E3TTZ7_ARGIR            Unreviewed;       459 AA.
AC   E3TTZ7;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Myostatin {ECO:0000313|EMBL:ADO32801.1};
OS   Argopecten irradians (Bay scallop) (Aequipecten irradians).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Pectinida; Pectinoidea; Pectinidae;
OC   Argopecten.
OX   NCBI_TaxID=31199 {ECO:0000313|EMBL:ADO32801.1};
RN   [1] {ECO:0000313|EMBL:ADO32801.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21554355; DOI=10.1111/j.1365-2052.2011.02172.x;
RA   Guo L., Li L., Zhang S., Guo X., Zhang G.;
RT   "Novel polymorphisms in the myostatin gene and their association with
RT   growth traits in a variety of bay scallop, Argopecten irradians.";
RL   Anim. Genet. 42:339-340(2011).
RN   [2] {ECO:0000313|EMBL:ADO32801.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Guo L., Li L., Zhang S., Zhang G.;
RT   "Molecular cloning and characterization of the myostatin gene in a
RT   cultivated variety of bay scallop, Argopecten irradians.";
RL   Aquaculture 350-353:192-199(2012).
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; JN684903; ADL60139.1; -; mRNA.
DR   EMBL; JN684902; ADO32801.1; -; Genomic_DNA.
DR   AlphaFoldDB; E3TTZ7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13751; TGF_beta_GDF8_like; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF291; LD29161P; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..459
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007653703"
FT   DOMAIN          339..459
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   459 AA;  53375 MW;  D7F959DB40CB51EF CRC64;
     MHHICHPLLF SVLFSAVYAV AINQPNNTYQ TLEQVNKDLP SIPKHDTLTD EIYDDDYYSE
     LALERARAKN NIEYEYDMLN DTANSTDYYY YEEIEQVKNP KQQKCQMCTI RDEQKRHRVE
     AIKNRISHVL KLDVLGMPNT TAKRLPKVPS FLRLREKYEN AQMQSDSPNS RKEEKLRYQD
     VQEEYGQPER TYSFARELPA EMDQQFPNTI YFDMQDSPEK ETNKALLWVY ISPDDIIDRN
     MTEIYVYTID PPGKFSKVPT KREIGRRKRH YMKASGWHHF DILDEVQKWT YRTHLNLGLV
     VEALDETGHN LVVLPPTFGD DDGYEPMLDL RTSLRKSTRS KRSTELYCDT REETACCRYP
     LEVDFVAFGW DFVIAPLTYA AYYCAGECKG EQLDDTLHAH VIQQAPSPTL SQPQSAISNV
     GPCCTPTKMS DLAMLFFDHN SNIALTRLPR MKVDRCGCA
//