ID   E4KR05_9LACT            Unreviewed;       339 AA.
AC   E4KR05;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=DUF218 domain-containing protein {ECO:0000259|Pfam:PF02698};
GN   ORFNames=HMPREF9257_0717 {ECO:0000313|EMBL:EFR30720.1};
OS   Eremococcus coleocola ACS-139-V-Col8.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Eremococcus.
OX   NCBI_TaxID=908337 {ECO:0000313|EMBL:EFR30720.1, ECO:0000313|Proteomes:UP000005990};
RN   [1] {ECO:0000313|EMBL:EFR30720.1, ECO:0000313|Proteomes:UP000005990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACS-139-V-Col8 {ECO:0000313|EMBL:EFR30720.1,
RC   ECO:0000313|Proteomes:UP000005990};
RA   Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA   Nelson K.E.;
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFR30720.1}.
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DR   EMBL; AENN01000017; EFR30720.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4KR05; -.
DR   STRING; 908337.HMPREF9257_0717; -.
DR   eggNOG; COG1434; Bacteria.
DR   OrthoDB; 9782395at2; -.
DR   Proteomes; UP000005990; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd06259; YdcF-like; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR003848; DUF218.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR30336; INNER MEMBRANE PROTEIN, PROBABLE PERMEASE; 1.
DR   PANTHER; PTHR30336:SF18; MEMBRANE PROTEIN-RELATED; 1.
DR   Pfam; PF02698; DUF218; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005990};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          162..310
FT                   /note="DUF218"
FT                   /evidence="ECO:0000259|Pfam:PF02698"
SQ   SEQUENCE   339 AA;  39574 MW;  E1224476401E9091 CRC64;
     MMYYGLAVIF FGLAFFFYRK KQGPYPDMVW IFYGLTSLLT GFMVTSSMRF FATIRLFVYI
     ASGFVIAFLP IFLVVLLGTL FKDMQEKHEQ AWYRVITGLM VMLLSAAIIF MVWGAFNLQE
     IRFENYIDMV IEITLYFIAN FLAFCLLNWV LQVFPLKVKG QVLMVLGQKI DNPQQFPRLL
     ARRLDQALAY YIAQPLSDQN KIYFLVTGGP IAWGDTSEAA EMRDYLIERG VAGDKIILEP
     LAHNTFQNFY YGRELLVGPL KAAPVIVFTS RFHVLRSYCY GQASGMKATY RGTRVAWYLW
     PYYLIRDYLG FLLVVKHLNY LYLLLIFLVW LYQIIYGIY
//