ID E4LAN8_9FIRM Unreviewed; 852 AA.
AC E4LAN8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:EFR42184.1};
GN ORFNames=HMPREF9220_0175 {ECO:0000313|EMBL:EFR42184.1};
OS Dialister micraerophilus UPII 345-E.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Dialister.
OX NCBI_TaxID=910314 {ECO:0000313|EMBL:EFR42184.1, ECO:0000313|Proteomes:UP000004594};
RN [1] {ECO:0000313|EMBL:EFR42184.1, ECO:0000313|Proteomes:UP000004594}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UPII 345-E {ECO:0000313|EMBL:EFR42184.1,
RC ECO:0000313|Proteomes:UP000004594};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFR42184.1}.
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DR EMBL; AENT01000030; EFR42184.1; -; Genomic_DNA.
DR RefSeq; WP_007555234.1; NZ_AENT01000030.1.
DR AlphaFoldDB; E4LAN8; -.
DR eggNOG; COG0249; Bacteria.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000004594; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 683..699
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 609..616
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 852 AA; 97040 MW; FD70B7440E848463 CRC64;
MAKTPLMAQY QSIKDKYEDS LLFYRLGDFY ELFYDDAKVV SHELELTLTG KSAGKEGRVP
MCGVPYHAAE NYIYRLIQKG YKVAVCEQLE EPKKAKGLVK RDVIRVITPG TILFENAIAD
KSNNYLMYIY EEQGEIVLIL SDISTGECSW GIWNAKKELY DMFDMISIYQ PSETLCTISD
EIYEKTDYFF TSSVGGCLLV RKEYTDEIKE NDVIYSDNKK VQKAFLLLVE YLKDVMKSDS
VKFHNIYKLR EDHVLHLSEK TIRNLEITKN MRDGGRKGTL LELLDYTSTA MGGRLLKKWL
EQPLTDVNRI ILRQNGIEEL RTHATELQKL ESLFSSIFDF ERILARIEAN TTSPKDLLSL
KSTLKEIPEI KKVLSGASSV ILKNINSNIK THKFVYELLD KSMNENGTGS IRDGKYIKNG
YSKELDEVRS LAENSRKWIT ELEKSEKEKT GIKLKIGFNN IFGYYFEITH ANKIPIPEYY
VRKQTLVNAE RYITPELKEF EAKVLVAKEK MSELELELYK DIKKQIYPYI AEMQKTARTI
AGLDCLSGLA RAALKERYIK PVIECSKNKH ILINDGRHPM VEHALKNEMF IPNDIELNHV
NQELLVITGP NMAGKSTFMR QVAVLVIMAQ IGSFIPAKSA VISPVDRIFT RVGATDDIST
GQSTFMVEMQ EVSHILKHAT ENSLVLLDEI GRGTSTYDGM SIAKAVVEYF DKNIHAYTLF
ATHYHELSDM ASTSKKIKNF TVTVKERGEE ITFLRRIVPG CADRSYGIHV ARLAGLPESL
LKQASAILDN LESQDNKSLN KTIMEKVENT SEENLFTSSI INELSTLDVM SKTPLEAMEI
LFRLSKEAKG GN
//
