ID   E4LEX2_9FIRM            Unreviewed;       283 AA.
AC   E4LEX2;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Oxidoreductase, aldo/keto reductase family protein {ECO:0000313|EMBL:EFR59458.1};
GN   ORFNames=HMPREF9199_1767 {ECO:0000313|EMBL:EFR59458.1};
OS   Veillonella sp. oral taxon 158 str. F0412.
OC   Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC   Veillonella.
OX   NCBI_TaxID=879309 {ECO:0000313|EMBL:EFR59458.1, ECO:0000313|Proteomes:UP000003565};
RN   [1] {ECO:0000313|EMBL:EFR59458.1, ECO:0000313|Proteomes:UP000003565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0412 {ECO:0000313|EMBL:EFR59458.1,
RC   ECO:0000313|Proteomes:UP000003565};
RA   Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA   Nelson K.E.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFR59458.1}.
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DR   EMBL; AENU01000019; EFR59458.1; -; Genomic_DNA.
DR   RefSeq; WP_009352270.1; NZ_AENU01000019.1.
DR   AlphaFoldDB; E4LEX2; -.
DR   STRING; 879309.HMPREF9199_1767; -.
DR   eggNOG; COG0656; Bacteria.
DR   OrthoDB; 9804790at2; -.
DR   Proteomes; UP000003565; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 2.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE   4: Predicted;
FT   DOMAIN          19..190
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   DOMAIN          202..259
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        53
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         111
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            78
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   283 AA;  32592 MW;  8A11AEA3AB778AE5 CRC64;
     MEERMDFRIL NNGSFIPSIG YGTYKTGSEG ETEQAVANAL GVGYRLLDTA AYYGNEEAVG
     RGIKASSVNR TDIIITTKIW HTDAGYDNTM RAVESSLKKL DTNYIDIMLV HQPLGDYYGS
     WRAMEELYDQ NVLRGLGLSN FYEDRLIDLL YHCNVKPVVN QIECHPFNQR QSLLQLMRKH
     QVVGMAWSPF TRDRQPIFDH PIIKSLAEKY GVTKHQIILR WHIQRGIIPL PKANTVSHME
     ANFDVFDFKL TNIDMDVMEL LDQQDFLEDH HTAPGLERLL QLR
//