ID E4MTW8_CAPOC Unreviewed; 603 AA.
AC E4MTW8;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Thiamine pyrophosphate enzyme, N-terminal TPP binding domain protein {ECO:0000313|EMBL:EFS96924.1};
GN Name=poxB {ECO:0000313|EMBL:EFS96924.1};
GN ORFNames=HMPREF1977_1840 {ECO:0000313|EMBL:EFS96924.1};
OS Capnocytophaga ochracea F0287.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=873517 {ECO:0000313|EMBL:EFS96924.1, ECO:0000313|Proteomes:UP000005391};
RN [1] {ECO:0000313|EMBL:EFS96924.1, ECO:0000313|Proteomes:UP000005391}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0287 {ECO:0000313|EMBL:EFS96924.1,
RC ECO:0000313|Proteomes:UP000005391};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFS96924.1}.
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DR EMBL; AEOH01000043; EFS96924.1; -; Genomic_DNA.
DR AlphaFoldDB; E4MTW8; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_0_10; -.
DR Proteomes; UP000005391; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 26..136
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 223..343
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 405..551
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 603 AA; 66457 MW; FB69380484F1059A CRC64;
MRLKIVLIGI IFAYKKPLII KHMSKNVSDQ LVEMLVQAGV KRVYAITGDS LNPVNDAIRR
DGRLEWIHVR HEESAAYAAS MDAELNGIGC CMGSSGPGHV HLINGLYDAN RSGNPVIAIA
STCATHKFGT HWFQETNPFL LFQDCSKYVY VANTPKQFTT MMQRAIQTAI NEKGVAVLGL
PGDVAGADLE EVPSATQTFL AKPVVRPSDS ELDKLSAVLN DAKNKKIALY CGHGCQYAVK
EVEQLAETLK APIVASFRGK IFFDRTDSPY IAGMNGLLGH RSGYDACAKA DVLVMLGIDF
PYAEFLPKKN TIIQIDERPD IIGRRAKVDY GFAGDVKDTI TALLPKLTPR TDDSFLKDIH
KEYLELEKSL DDYTKKKTEE NQIDPEYAAK LLDKYAANDA IFTVDTGMNV VWAARFIKGT
GKRYLTGSFN HGSMANALPM AIGAAASSKG RQVVAMCGDG GLSMLLGDLA TLMQYQYPVK
IFVFNNRSLA MVKLEMEVSG YLDWQTNMVN PPFDKLADLM NIKGYEVRKT EDLEATVKAA
FEHDGPTLVN IYTNRDTLAM PPHITFEQMK GFATNIIKKI GQGDFAEAKG SIANSMKHIK
DVF
//
