ID E4NIL9_KITSK Unreviewed; 1584 AA.
AC E4NIL9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Putative non-ribosomal peptide synthetase-polyketide synthase hybrid {ECO:0000313|EMBL:BAJ32817.1};
GN Name=nrps {ECO:0000313|EMBL:BAJ32817.1};
GN OrderedLocusNames=KSE_70590 {ECO:0000313|EMBL:BAJ32817.1};
OS Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS / NBRC 14216 / KM-6054) (Streptomyces setae).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ32817.1, ECO:0000313|Proteomes:UP000007076};
RN [1] {ECO:0000313|EMBL:BAJ32817.1, ECO:0000313|Proteomes:UP000007076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA Takahashi Y., Fujita N.;
RT "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT snapshot of the family Streptomycetaceae.";
RL DNA Res. 17:393-406(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; AP010968; BAJ32817.1; -; Genomic_DNA.
DR RefSeq; WP_014140108.1; NC_016109.1.
DR STRING; 452652.KSE_70590; -.
DR KEGG; ksk:KSE_70590; -.
DR PATRIC; fig|452652.3.peg.7093; -.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_2_4_11; -.
DR Proteomes; UP000007076; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007076};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1036..1113
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1158..1580
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 35..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1031
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1584 AA; 167137 MW; E93789EB11F448B8 CRC64;
MSTALRELLE AIAAGEVSED VAGPLLRSLV EAAPAAPAPS PAPAPAAAPA PTPTPYDPNP
YPLTRGQAAL WAIHESRPDA TSYNLPLGLW LGDQVDPDRL AEALIAAVER NPDLRIAVRL
DATGPVQVIT DRPVEVPRLD LGHVTDGEFT ARIDSLVRQP FDLEHDPLHR SWLITTPGGG
ALLLLVFHHL ITDGVSSHLL LRDIVACYDG LTSGRGLPPV EPATPYSEFV RWQREMLAGP
QAEEHRRWWL DRLGGASTAP VLQAIADRRR AGTASHTSGA MVQLRLPEAT WSAVRNTARR
AGVTTFGVVF GAFAALLQRH SGHRDISVMV PTDGRPEYRF DRTVGYLINP VVLRVDCDPR
LSFAELANAV QDEMVRAEDY GGYPFAAVVD DLRRGPDPDA EFGIGFYLQQ GVGGDQDMAA
GQTVFRDALD LTQESENDLV VEVVVRDTEA LLYVKYDTEL FDRPTVERLA EHYRLLLEAV
TADPDRRTAD LDLGTPEERG TLARVNATAA GRPRDVSTAQ LVLARAGRHP ERTAVVDAEG
ALTYAELAGR VRALTGVLRA RGVRPGDLVG VLTDRRAALI VALLAVQAAG AAYVPLDPDF
PAARLAHIGS DAGPAAVLLE PGLADRLPAD VPGERIPVDG PGTAAPAEPV ARRDADLAYV
LYTSGSTGQP KGVEVTHGNL VNLLTAMADR PGCAEDDVLL AVTTAGFDIA GLELLLPLTR
GATVHLAPAE TLRDGLALAE LLDRSGATLV QATPATWQML LHAGWTGRVR RILCGGEPLT
AGLAAQLFDR CDELWNMYGP TETTVWSSAL RVRRNRPVTV GTPIANTTFR VAGPDGAPVP
FGAVGELLIG GEGVARGYRN RPELTAERFP RDPASGERLY RTGDLARWSA TGELLLLGRA
DRQVKLRGHR IELGEVESAV RRHLGTGDVR VVVREDLPGT PQLVAFVTAA PEVAAEAVRR
ADELLPGYMV PARTVALARF PMTPNAKVDA GPLADLPHAE LLSRFGHPQE RSAPAAPAPA
PAAPPGARPP ARAADRPAGD LLARLREATA GVAGRPAEEV PVDRPLGEVG FDSVGFTRLA
VALRERLGVV VRPTVFYSHP DLASLAAHLA ATRPELAAPA APAAATAPAA ATTTATTTAT
PVAGPAAAAG APAAAVGYPP VAIIGIGGRL PSSASLEEFW GHLAAGRDLT RPYPLERGFS
ARLFPEGHRG SFVDDVDAFD PSLFRISPRE AAQMDPQHRL LLHAAHEALL DSGQLPAELA
GSRTGVFVGL SGADYLSLLG PGSPEMGDHF LIGNVASIAA NRISYVYDLS GPSAVFDTAC
SSSLVAVHRA ARALQYGDCE LALAGGANLL LAPHGFAGLR RAGMLSPDGR CKTFDERADG
YGRGEGVVLL ALKLLDRALA DGDPVHAVLI GSAENHGGHT HSLTVPNPQA QREVVLAAHR
AAGIPPDTVG YIEAHGTGTP LGDPIEVDAL KEAFTRLYDD WGIPVVPGRT GVGSVKTNIG
HLEAAAGVAG IVKVVLAMRH RTLPGLVDLR TPNPMLDFAD SPLRIQSAAQ AWETPDGAPA
RAGVSSFGMG GSNVHVVIEE AGER
//
