ID E4NJY5_KITSK Unreviewed; 559 AA.
AC E4NJY5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Putative benzoylformate decarboxylase {ECO:0000313|EMBL:BAJ33283.1};
DE EC=4.1.1.7 {ECO:0000313|EMBL:BAJ33283.1};
GN OrderedLocusNames=KSE_75300 {ECO:0000313|EMBL:BAJ33283.1};
OS Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304
OS / NBRC 14216 / KM-6054) (Streptomyces setae).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ33283.1, ECO:0000313|Proteomes:UP000007076};
RN [1] {ECO:0000313|EMBL:BAJ33283.1, ECO:0000313|Proteomes:UP000007076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T., Horinouchi S.,
RA Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A., Nomoto F., Miura H.,
RA Takahashi Y., Fujita N.;
RT "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT snapshot of the family Streptomycetaceae.";
RL DNA Res. 17:393-406(2010).
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; AP010968; BAJ33283.1; -; Genomic_DNA.
DR RefSeq; WP_014140574.1; NC_016109.1.
DR AlphaFoldDB; E4NJY5; -.
DR STRING; 452652.KSE_75300; -.
DR KEGG; ksk:KSE_75300; -.
DR PATRIC; fig|452652.3.peg.7576; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_1_11; -.
DR Proteomes; UP000007076; Chromosome.
DR GO; GO:0050695; F:benzoylformate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02002; TPP_BFDC; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF133; BENZOYLFORMATE DECARBOXYLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:BAJ33283.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007076};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 26..130
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 219..345
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 408..552
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 58003 MW; F1489A645F893DC8 CRC64;
MLNSTAHTDV LVPAPGRRPG PAPEVTGTEA LLDVLVSEGV RHVFGNPGTT ELPLLAGLEP
AGIGFVLGLH EAVAVGMADG YARLTGRPAF VNLHSTAGLG NGLGVLTNSA AAGTPLVVTA
GQQDYRHIAQ EPLLSGRLAE LAAPLVKWSH EARSRHELAV MGRRAFQLAA ARPTGPVFLS
LPVNFLDEAG PGAPARSTVL PAAGGEVTDL ADLLLATPAG RLALVYGDEV TGSTAAEEGR
RLAELLDAPV YGPSWPGSNP FPTDHPLWRG FLHAGPDGFA TSLAGHDRVL VVGGRALTGY
VYTPAPLLPA RVELLQITAD PAALGRQQAL RLGVVGDVGT TLAALRAAIG TRRRPPGQPH
PATAGPAPDP VAAAPSRLTH DAVARVVADT LPRDAYLVEE ALSTRPALWR HLRLPTAGRY
LAPANAGLGW AMPAACGAAL AAGGAPVLCV VGDGAALYTP QSLWNAAHQH LPVTFLVVNN
TRYQVLDTNW HRMRPDDPTP PPLPGLDLVS PAVRFSSLAH AMGIESHTVD TPTALHDVLT
RAFEEPGPRL VEALLPDGS
//
