ID   E4NKX5_HALBP            Unreviewed;       711 AA.
AC   E4NKX5;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   OrderedLocusNames=Hbor_15570 {ECO:0000313|EMBL:ADQ67127.1};
OS   Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 /
OS   KCTC 4070 / PR3).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Halogeometricum.
OX   NCBI_TaxID=469382 {ECO:0000313|EMBL:ADQ67127.1, ECO:0000313|Proteomes:UP000006663};
RN   [1] {ECO:0000313|EMBL:ADQ67127.1, ECO:0000313|Proteomes:UP000006663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700274 / DSM 11551 / JCM 10706 / KCTC 4070 / PR3
RC   {ECO:0000313|Proteomes:UP000006663};
RX   PubMed=21304651; DOI=10.4056/sigs.23264;
RA   Malfatti S., Tindall B.J., Schneider S., Fahnrich R., Lapidus A.,
RA   Labuttii K., Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S.,
RA   Tice H., Cheng J.F., Bruce D., Goodwin L., Pitluck S., Anderson I.,
RA   Pati A., Ivanova N., Mavromatis K., Chen A., Palaniappan K.,
RA   D'haeseleer P., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P., Chain P.;
RT   "Complete genome sequence of Halogeometricum borinquense type strain
RT   (PR3).";
RL   Stand. Genomic Sci. 1:150-159(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
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DR   EMBL; CP001690; ADQ67127.1; -; Genomic_DNA.
DR   AlphaFoldDB; E4NKX5; -.
DR   STRING; 469382.Hbor_15570; -.
DR   ESTHER; halbp-e4nkx5; S9N_PPCE_Peptidase_S9.
DR   MEROPS; S09.076; -.
DR   KEGG; hbo:Hbor_15570; -.
DR   eggNOG; arCOG01647; Archaea.
DR   HOGENOM; CLU_011290_1_1_2; -.
DR   Proteomes; UP000006663; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ADQ67127.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006663};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          35..440
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          506..708
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          26..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  78742 MW;  E99EE33C3FAFC645 CRC64;
     MISALSDRHS RGDGFRNPEI LVTICSRTRM DSPPETDQRD TGYTLHDDDI DDPYLWLEET
     DDDVSAWTAA QNDYADDYLD SLDIRESLRP RFEDLARTTT YMPVKARQNG YFQRVRDADA
     DHPVLTFRPG LNEDRRVLGD PNEMSDDGSV SVDWYVPNPD GSLVAYGVAE GGDEQYDVRV
     LETESGETAE ELTDVGRTGP WCFGWTDDGF YYLTTGSVGD GGQLEKEVCF HEIGTDPADD
     WTLADEFSTQ TWPLVETDAE SDYVILGHTE GWERTDLYYA ELGSDELHPL VVGEDALFEP
     TLDGNDVYVN TSLDASNYRV VSVSLDAVDP SASPTDVGES STDPNKPFET VVAERDDAIA
     QELDVIGDRI VVKYLRDAVH ELVVFDADGE QDETVPLPGR GSVASFGGED DLFFTYESFT
     EPPSIRRYAF GADETTVVDQ PDISTETDLT VTQDWFASAD GTEVPAFVVR RSDLECDGDN
     PAVLYGYGGF ENSLTPFFGE FFLPFLESGG VLAVANLRGG GEFGESWHHA GRREHKQRVF
     DDFFAAAEHL VENGYTSTER LACFGGSNGG LLVGASITQR PDLFAAAVCK VPLLDMLRFH
     TSLLGETWTT EYGSPDDPEA YEYIREYSPY HNVEERAYPA VLFTTGESDS RVDPFHARKM
     AARMQAAQSG ADPILLKTRS QTGHGSGKPV SKVVEENLDE WSFLGDQLDA F
//