ID E4PSV5_MYCLG Unreviewed; 678 AA.
AC E4PSV5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=protein-N(pi)-phosphohistidine--D-fructose phosphotransferase {ECO:0000256|ARBA:ARBA00012799};
DE EC=2.7.1.202 {ECO:0000256|ARBA:ARBA00012799};
GN OrderedLocusNames=MSB_A0911 {ECO:0000313|EMBL:ADR24657.1};
OS Mycoplasma leachii (strain DSM 21131 / NCTC 10133 / N29 / PG50).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=880447 {ECO:0000313|EMBL:ADR24657.1, ECO:0000313|Proteomes:UP000008712};
RN [1] {ECO:0000313|Proteomes:UP000008712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21131 / NCTC 10133 / N29 / PG50
RC {ECO:0000313|Proteomes:UP000008712};
RA Wise K., Calcutt M.J., Foecking M.F., Madupu R., DeBoy R.T., Roske K.,
RA Martin T.R., Hvinden M.L., Durkin A.S., Glass J., Methe B.A.;
RT "Genome sequence of Mycoplasma leachii PG50 MU clone A8.";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADR24657.1, ECO:0000313|Proteomes:UP000008712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21131 / NCTC 10133 / N29 / PG50
RC {ECO:0000313|Proteomes:UP000008712};
RX PubMed=22843585; DOI=10.1128/JB.00761-12;
RA Wise K.S., Calcutt M.J., Foecking M.F., Madupu R., Deboy R.T., Roske K.,
RA Hvinden M.L., Martin T.R., Durkin A.S., Glass J.I., Methe B.A.;
RT "Complete Genome Sequences of Mycoplasma leachii Strain PG50T and the
RT Pathogenic Mycoplasma mycoides subsp. mycoides Small Colony Biotype Strain
RT Gladysdale.";
RL J. Bacteriol. 194:4448-4449(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC fructose 1-phosphate(in) + L-histidyl-[protein];
CC Xref=Rhea:RHEA:49252, Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746,
CC ChEBI:CHEBI:29979, ChEBI:CHEBI:37721, ChEBI:CHEBI:58674,
CC ChEBI:CHEBI:64837; EC=2.7.1.202;
CC Evidence={ECO:0000256|ARBA:ARBA00001401};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002108; ADR24657.1; -; Genomic_DNA.
DR RefSeq; WP_013448136.1; NC_014751.1.
DR AlphaFoldDB; E4PSV5; -.
DR KEGG; mlc:MSB_A0911; -.
DR eggNOG; COG1299; Bacteria.
DR eggNOG; COG1445; Bacteria.
DR eggNOG; COG1762; Bacteria.
DR HOGENOM; CLU_013155_1_0_14; -.
DR OrthoDB; 9782569at2; -.
DR Proteomes; UP000008712; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd00211; PTS_IIA_fru; 1.
DR CDD; cd05569; PTS_IIB_fructose; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR InterPro; IPR036095; PTS_EIIB-like_sf.
DR InterPro; IPR013011; PTS_EIIB_2.
DR InterPro; IPR003501; PTS_EIIB_2/3.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR004715; PTS_IIA_fruc.
DR InterPro; IPR003353; PTS_IIB_fruc.
DR InterPro; IPR006327; PTS_IIC_fruc.
DR NCBIfam; TIGR00829; FRU; 1.
DR NCBIfam; TIGR00848; fruA; 1.
DR NCBIfam; TIGR01427; PTS_IIC_fructo; 1.
DR PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR PANTHER; PTHR30505:SF0; FRUCTOSE-LIKE PTS SYSTEM EIIBC COMPONENT-RELATED; 1.
DR Pfam; PF00359; PTS_EIIA_2; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR Pfam; PF02302; PTS_IIB; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR PROSITE; PS00372; PTS_EIIA_TYPE_2_HIS; 1.
DR PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Pyruvate {ECO:0000313|EMBL:ADR24657.1};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADR24657.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..149
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000259|PROSITE:PS51094"
FT DOMAIN 165..261
FT /note="PTS EIIB type-2"
FT /evidence="ECO:0000259|PROSITE:PS51099"
FT DOMAIN 289..663
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000259|PROSITE:PS51104"
SQ SEQUENCE 678 AA; 73588 MW; C57245C88E61ECC9 CRC64;
MQIKDLFNQN TSFFKQEFKT KTQIIDFLVS KLLEQKIISK KTAVLNAIKT REKLESTAIG
DGIAIPHALN EAVLKPTVCF MSLKTPIKWN NNDNQLVDLV FMIVTNDQNG NDHMDAIADL
SSKFLDSSVL NKLREIESFI ELVEIFDDKK ELKEEQINKN EFFDVVGITA CPTGIAHTYL
ASDKLTEYAK SLNLSIKIET QGRRGIENKL TEQDIKNAKV IILAHDKAIE GMSRFNNCKV
IDTSTKDAIY NGKELISNFD KHPKLKEIKN IKADDSTIGE LSLKKFKDFK GNLLGGVSRM
LPFVVAGGII LGIGFLLDFI TGNGNAKGDF GTVNKVSGWF AAAGKTAMMM MVPILGGYIA
YAIVGPQGLM PGVVAGLLAD NTGGFAYGTI GSWSGLWKRI LPEHLPTSSG FIGAMVGGYL
TAFIVFGLTV GMQKFKKPFH GVRDIVFIPI LSLLGISLTM FVLNIPLGYL LYGIQLGLTY
MAKNNLLIIL GAIIGLMMCV DMGGPINKIA YVLGTASVAG SFGKEAIFTN VMAASMAGGM
IPPLGIALCT VLFKKVWTSK ERDAAKANWL MGSFFISEGA IPFMITDPKH ISVSALSGGF
ATGLLVGAFK ITLPAPHGGI FIFPLLNSEL FTKHSVAKGM GIALFILAIL IGTLVMTLIL
GFWKKVDISK GYLQIVET
//
