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Database: UniProt
Entry: E4Q8X5_CALH1
LinkDB: E4Q8X5_CALH1
Original site: E4Q8X5_CALH1 
ID   E4Q8X5_CALH1            Unreviewed;       607 AA.
AC   E4Q8X5;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   OrderedLocusNames=Calhy_1174 {ECO:0000313|EMBL:ADQ06894.1};
OS   Caldicellulosiruptor hydrothermalis (strain DSM 18901 / VKM B-2411 / 108).
OC   Bacteria; Bacillota; Clostridia; Caldicellulosiruptorales;
OC   Caldicellulosiruptoraceae; Caldicellulosiruptor.
OX   NCBI_TaxID=632292 {ECO:0000313|EMBL:ADQ06894.1, ECO:0000313|Proteomes:UP000006890};
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=108;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N.,
RA   Mikhailova N., Blumer-Schuette S.E., Kelly R.M., Woyke T.;
RT   "Complete sequence of Caldicellulosiruptor hydrothermalis 108.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADQ06894.1, ECO:0000313|Proteomes:UP000006890}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18901 / VKM B-2411 / 108
RC   {ECO:0000313|Proteomes:UP000006890};
RX   PubMed=21216991; DOI=10.1128/JB.01515-10;
RA   Blumer-Schuette S.E., Ozdemir I., Mistry D., Lucas S., Lapidus A.,
RA   Cheng J.F., Goodwin L.A., Pitluck S., Land M.L., Hauser L.J., Woyke T.,
RA   Mikhailova N., Pati A., Kyrpides N.C., Ivanova N., Detter J.C.,
RA   Walston-Davenport K., Han S., Adams M.W., Kelly R.M.;
RT   "Complete genome sequences for the anaerobic, extremely thermophilic plant
RT   biomass-degrading bacteria Caldicellulosiruptor hydrothermalis,
RT   Caldicellulosiruptor kristjanssonii, Caldicellulosiruptor kronotskyensis,
RT   Caldicellulosiruptor owensenis, and Caldicellulosiruptor lactoaceticus.";
RL   J. Bacteriol. 193:1483-1484(2011).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000256|ARBA:ARBA00003926, ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362098};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362098}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
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DR   EMBL; CP002219; ADQ06894.1; -; Genomic_DNA.
DR   RefSeq; WP_013403074.1; NC_014652.1.
DR   AlphaFoldDB; E4Q8X5; -.
DR   STRING; 632292.Calhy_1174; -.
DR   KEGG; chd:Calhy_1174; -.
DR   eggNOG; COG0370; Bacteria.
DR   HOGENOM; CLU_013350_6_0_9; -.
DR   OMA; CITSFAM; -.
DR   OrthoDB; 9809127at2; -.
DR   Proteomes; UP000006890; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   NCBIfam; TIGR00437; feoB; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43185:SF1; FE(2+) TRANSPORTER FEOB; 1.
DR   PANTHER; PTHR43185; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR603373-
KW   1}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496,
KW   ECO:0000256|RuleBase:RU362098};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR603373-2};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362098};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR603373-2};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRSR:PIRSR603373-1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM        246..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        288..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        318..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        362..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        396..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        482..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        555..573
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        585..606
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   DOMAIN          16..172
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51711"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT   BINDING         34
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         37
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         38
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         48..52
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT   BINDING         65..68
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT   BINDING         123..126
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
SQ   SEQUENCE   607 AA;  67674 MW;  C4CE5CBDB5EDCD07 CRC64;
     MNCHCVQEML NIPDDKEVIA LVGNPNVGKS VIFNKLTGRY VEVSNYPGTT VDVNYGFYKD
     YVIVDTPGVY GISSFNDEEI VTRDIVLNTQ KIINVVDSVH LDRDLFLTQQ LIDYQKEVIV
     VLNMVDEVEK NNIKIDIEKL KESLGVEVIA TSASKGIGID KLREAIDKNL FKKGKSTPNL
     EKILESEGKK FSWESLAEAE NVFSSSVSEL QEKIFALRRT YVDEIFNKTV KFDTKKLEFK
     NKLSQVLINP VTGIPILFAT MYIMYYFMGV LVAQRLVDFT MNTVMGEYYL GLIKGIVGKF
     VTNLFLQKII VGNYGILSMF PIIFFGLLFP LVVAFHLFMS ILEDSGYLPR IAALVDRVFN
     KIGLNGRAII PIILGFGCVT MATMTTRILG SKRERLITMF LLGLTIPCSA QLGIISGLIS
     RLGFWYLVAY ILIIAFIFGL VGRILNKIIK GESTSLFIDL PTLRIPQPSN VLKKTYYKSK
     GFLVEAFPIF VAATLVLGFL DATNLLHAIE NFAQPVVTGF LKLPKEITEV FILGIIRRDY
     GAAGLVTIPT TKGQMFVALV TTTLFVPCIT SFAMMTKENG LKYSVFVWVS SAVIAILVGG
     ILAHIIL
//
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