ID E4RM60_HALHG Unreviewed; 299 AA.
AC E4RM60;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Formylmethanofuran--tetrahydromethanopterin formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
DE Short=Ftr {ECO:0000256|HAMAP-Rule:MF_00579};
DE EC=2.3.1.101 {ECO:0000256|HAMAP-Rule:MF_00579};
DE AltName: Full=H4MPT formyltransferase {ECO:0000256|HAMAP-Rule:MF_00579};
GN Name=ffsA {ECO:0000256|HAMAP-Rule:MF_00579};
GN OrderedLocusNames=Halsa_0945 {ECO:0000313|EMBL:ADQ14391.1};
OS Halanaerobium hydrogeniformans (Halanaerobium sp. (strain sapolanicus)).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halanaerobiaceae;
OC Halanaerobium.
OX NCBI_TaxID=656519 {ECO:0000313|EMBL:ADQ14391.1, ECO:0000313|Proteomes:UP000007434};
RN [1] {ECO:0000313|EMBL:ADQ14391.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA Begemann M.B., Mormile M.R., Wall J.D., Elias D.A., Woyke T.;
RT "Complete sequence of Halanaerobium sp. sapolanicus.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ14391.1, ECO:0000313|Proteomes:UP000007434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=sapolanicus {ECO:0000313|Proteomes:UP000007434};
RX PubMed=21602336; DOI=10.1128/JB.05209-11;
RA Brown S.D., Begemann M.B., Mormile M.R., Wall J.D., Han C.S., Goodwin L.A.,
RA Pitluck S., Land M.L., Hauser L.J., Elias D.A.;
RT "Complete Genome Sequence of the Haloalkaliphilic, Hydrogen Producing
RT Halanaerobium hydrogenoformans.";
RL J. Bacteriol. 193:3682-3683(2011).
CC -!- FUNCTION: Catalyzes the transfer of a formyl group from 5-formyl
CC tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to
CC produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin
CC (H(4)MPT). {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran
CC = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin;
CC Xref=Rhea:RHEA:18061, ChEBI:CHEBI:15378, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58018, ChEBI:CHEBI:58103, ChEBI:CHEBI:58151;
CC EC=2.3.1.101; Evidence={ECO:0000256|HAMAP-Rule:MF_00579};
CC -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from
CC formaldehyde (H(4)MPT route): step 4/5. {ECO:0000256|HAMAP-
CC Rule:MF_00579}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579}.
CC -!- SIMILARITY: Belongs to the FTR family. {ECO:0000256|ARBA:ARBA00006770,
CC ECO:0000256|HAMAP-Rule:MF_00579}.
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DR EMBL; CP002304; ADQ14391.1; -; Genomic_DNA.
DR RefSeq; WP_013405481.1; NC_014654.1.
DR AlphaFoldDB; E4RM60; -.
DR STRING; 656519.Halsa_0945; -.
DR KEGG; has:Halsa_0945; -.
DR eggNOG; COG2037; Bacteria.
DR HOGENOM; CLU_081314_0_0_9; -.
DR OrthoDB; 8841169at2; -.
DR UniPathway; UPA00562; UER00704.
DR Proteomes; UP000007434; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030270; F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046294; P:formaldehyde catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.520; -; 2.
DR HAMAP; MF_00579; FTR; 1.
DR InterPro; IPR014053; ForMFR_H4MPT_ForTrfase.
DR InterPro; IPR002770; ForMFR_H4MPT_ForTrfase_C.
DR InterPro; IPR023447; ForMFR_H4MPT_ForTrfase_fd-like.
DR InterPro; IPR022667; ForMFR_H4MPT_ForTrfase_N.
DR NCBIfam; TIGR03119; one_C_fhcD; 1.
DR Pfam; PF01913; FTR; 1.
DR Pfam; PF02741; FTR_C; 1.
DR PIRSF; PIRSF006414; Ftr_formyl_trnsf; 1.
DR SUPFAM; SSF55112; Formylmethanofuran:tetrahydromethanopterin formyltransferase; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|HAMAP-Rule:MF_00579,
KW ECO:0000313|EMBL:ADQ14391.1}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00579};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_00579};
KW Reference proteome {ECO:0000313|Proteomes:UP000007434};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00579}.
FT DOMAIN 1..143
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01913"
FT DOMAIN 146..292
FT /note="Formylmethanofuran: tetrahydromethanopterin
FT formyltransferase Ftr C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02741"
SQ SEQUENCE 299 AA; 32588 MW; 484D0C8DDAFAC63B CRC64;
MQFQGIEIEN TFAEAFNMYG TRIIVTADNK KWAKIAARES TGFATSIIEC GIEAGIEREL
REEETLDGRP GYSLLFFTMK KDNLQKELRK RIGQTIMTAA TAACYNGLKS QEEIKVGSNI
RYFGDGYQIS KLYDKRRFWR IPIMGGEFLI EESFGIKKGL GGGNIIIVAE DQKKALNAAE
KAVEAMKEVE GIIMPFPGGI VSSGSKVKSK YSFLNASTNT PYCPTIKAQV ESELPAEAGS
VLEIVIDGLS VKAVEEAMKV GVKAAAVQGV IKITAGNYGG DLGSENIYLH EILRGGLSE
//