ID E4RSD7_LEAB4 Unreviewed; 410 AA.
AC E4RSD7;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=RNA-directed DNA polymerase (Reverse transcriptase) {ECO:0000313|EMBL:ADQ17673.1};
GN OrderedLocusNames=Lbys_1382 {ECO:0000313|EMBL:ADQ17098.1}, Lbys_1977
GN {ECO:0000313|EMBL:ADQ17673.1}, Lbys_1978
GN {ECO:0000313|EMBL:ADQ17674.1};
OS Leadbetterella byssophila (strain DSM 17132 / JCM 16389 / KACC 11308 / NBRC
OS 106382 / 4M15).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Leadbetterella.
OX NCBI_TaxID=649349 {ECO:0000313|EMBL:ADQ17673.1, ECO:0000313|Proteomes:UP000007435};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17132;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Teshima H., Brettin T., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B.,
RA Pomrenke H.G., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Leadbetterella byssophila DSM 17132.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADQ17673.1, ECO:0000313|Proteomes:UP000007435}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17132 {ECO:0000313|EMBL:ADQ17673.1}, and DSM 17132 / JCM
RC 16389 / KACC 11308 / NBRC 106382 / 4M15
RC {ECO:0000313|Proteomes:UP000007435};
RX PubMed=21475582; DOI=10.4056/sigs.1413518;
RA Abt B., Teshima H., Lucas S., Lapidus A., Del Rio T.G., Nolan M., Tice H.,
RA Cheng J.F., Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K.,
RA Pati A., Tapia R., Han C., Goodwin L., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Rohde M., Goker M., Tindall B.J.,
RA Detter J.C., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Leadbetterella byssophila type strain
RT (4M15).";
RL Stand. Genomic Sci. 4:2-12(2011).
CC -!- SIMILARITY: Belongs to the bacterial reverse transcriptase family.
CC {ECO:0000256|ARBA:ARBA00034120}.
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DR EMBL; CP002305; ADQ17098.1; -; Genomic_DNA.
DR EMBL; CP002305; ADQ17673.1; -; Genomic_DNA.
DR EMBL; CP002305; ADQ17674.1; -; Genomic_DNA.
DR RefSeq; WP_013408147.1; NC_014655.1.
DR AlphaFoldDB; E4RSD7; -.
DR KEGG; lby:Lbys_1382; -.
DR KEGG; lby:Lbys_1977; -.
DR KEGG; lby:Lbys_1978; -.
DR eggNOG; COG3344; Bacteria.
DR HOGENOM; CLU_013584_2_0_10; -.
DR OrthoDB; 9780724at2; -.
DR Proteomes; UP000007435; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd01651; RT_G2_intron; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR030931; Group_II_RT_mat.
DR InterPro; IPR013597; Mat_intron_G2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000123; Reverse_transcriptase_msDNA.
DR InterPro; IPR000477; RT_dom.
DR NCBIfam; TIGR04416; group_II_RT_mat; 1.
DR PANTHER; PTHR34047:SF3; BLR2052 PROTEIN; 1.
DR PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF08388; GIIM; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00866; RNADNAPOLMS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ADQ17673.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007435};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:ADQ17673.1};
KW Transferase {ECO:0000313|EMBL:ADQ17673.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..291
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 410 AA; 48576 MW; 9D0033CBF4D815B6 CRC64;
MIDYYETKQH PITKKMVLDA YRKVRANKGS AGIDTQSLEQ FEERLADNLY KIWNRMTSGS
YHPKAVREVQ IPKKSGGYRG LGIPTVSDRV AQQVVKSYLE PKVEPSFHQD SYGYRPNKSA
HDALAKTVRN CGYYSWVVDL DIRGFFDNID HELLMKAVRV YTDEKWIIMY IERWLEVGVV
REGKVHKREK GTPQGGVISP LLANIFLHFV FDKWMEKHHG NMPFERYCDD AIIHCTTWNQ
AVFIKNAVTK RMKECKLELN SEKTKIVYCK NSIHRESNPV PVSFTFLGHT FRPLGRPTKN
GWKLTYFPCM SQDAKKSVRE KVKSVVNRRF MGKLQDIAQR LNAMARGWIN YYCVYSRWTV
YGLWYWINLK LVRWVMRRKK MGRRRAHQWL RKIYNQNPKL FIHWTLARPY
//
