ID E4SIL2_LACAR Unreviewed; 588 AA.
AC E4SIL2;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=LA2_05250 {ECO:0000313|EMBL:ADQ59011.1};
OS Lactobacillus amylovorus (strain GRL 1112).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=695560 {ECO:0000313|EMBL:ADQ59011.1, ECO:0000313|Proteomes:UP000007033};
RN [1] {ECO:0000313|EMBL:ADQ59011.1, ECO:0000313|Proteomes:UP000007033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GRL 1112 {ECO:0000313|EMBL:ADQ59011.1,
RC ECO:0000313|Proteomes:UP000007033};
RX PubMed=21131492; DOI=10.1128/JB.01365-10;
RA Kant R., Paulin L., Alatalo E., de Vos W.M., Palva A.;
RT "Genome sequence of Lactobacillus amylovorus GRL1112.";
RL J. Bacteriol. 193:789-790(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CP002338; ADQ59011.1; -; Genomic_DNA.
DR RefSeq; WP_013437809.1; NC_014724.1.
DR AlphaFoldDB; E4SIL2; -.
DR KEGG; lam:LA2_05250; -.
DR PATRIC; fig|695560.3.peg.1047; -.
DR HOGENOM; CLU_001103_14_3_9; -.
DR Proteomes; UP000007033; Chromosome.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ADQ59011.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 24..193
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 218..364
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 515..588
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 588 AA; 66548 MW; 71F056E451B177EE CRC64;
MNPEKVLKQT FGYDSFRPGQ KKVIDLVLSK QNVLAVMPTG AGKSLCYQVP ALMNAGVTLV
ISPLISLMKD QIDTLKQNGI NAAALNSATP QEEVNPILRQ AYEGKIKLIY ITPERLAIDY
FRYQLNFLDI DLVAVDEAHC ISQWGHDFRP AYRQLLDGIN SLKSRPNILA LTATATPAVQ
DDICEQLNIP KQNMIITSFA RPNLSFKVVN SPQNTPLYIA QYIKMHPDEA GIIYTNTRKK
VESLTDYLAK KGISVGAYHG GMETKERDEV QEAFQFDQVQ VIVATNAFGM GIDKSNVRFV
IHASSARNIE SYYQEAGRAG RDGEESEAIM IYHPGDLRQY RFFIDESTAD EKYRELQYQK
LQAITDYANT GECLQQFIVR YFGQDCEPCG KCSNCLNQDE LTDITADAQK VISMVYELDG
RFGKNVVAQC LVGSNNQKMK EMNASQYDHF GSLKMNQKET ISLIDYLIAS RYLEIEGTKY
PLVHVTNRGW DVLDGKITVK RRIAKVQKKK QIFAQDENPD LYEALRKKRM ELAKKQRVPA
FMIFSDRSLH DMAKIKPQNE AEFLEVSGVG QAKMQKYGAT MIQVIKSF
//
