ID E4TQ88_MARTH Unreviewed; 386 AA.
AC E4TQ88;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=2-isopropylmalate synthase {ECO:0000256|ARBA:ARBA00012973};
DE EC=2.3.3.13 {ECO:0000256|ARBA:ARBA00012973};
GN OrderedLocusNames=Ftrac_1645 {ECO:0000313|EMBL:ADR21634.1};
OS Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408
OS / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Marivirgaceae; Marivirga.
OX NCBI_TaxID=643867 {ECO:0000313|EMBL:ADR21634.1, ECO:0000313|Proteomes:UP000008720};
RN [1] {ECO:0000313|EMBL:ADR21634.1, ECO:0000313|Proteomes:UP000008720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 /
RC H-43 {ECO:0000313|Proteomes:UP000008720};
RX PubMed=21677852; DOI=10.4056/sigs.1623941;
RA Pagani I., Chertkov O., Lapidus A., Lucas S., Del Rio T.G., Tice H.,
RA Copeland A., Cheng J.F., Nolan M., Saunders E., Pitluck S., Held B.,
RA Goodwin L., Liolios K., Ovchinikova G., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Jeffries C.D., Detter J.C.,
RA Han C., Tapia R., Ngatchou-Djao O.D., Rohde M., Goker M., Spring S.,
RA Sikorski J., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Marivirga tractuosa type strain (H-43).";
RL Stand. Genomic Sci. 4:154-162(2011).
CC -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine
CC from 3-methyl-2-oxobutanoate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004689}.
CC -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC family. {ECO:0000256|RuleBase:RU003523}.
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DR EMBL; CP002349; ADR21634.1; -; Genomic_DNA.
DR RefSeq; WP_013453781.1; NC_014759.1.
DR AlphaFoldDB; E4TQ88; -.
DR STRING; 643867.Ftrac_1645; -.
DR KEGG; mtt:Ftrac_1645; -.
DR eggNOG; COG0119; Bacteria.
DR HOGENOM; CLU_022158_3_1_10; -.
DR OrthoDB; 9804858at2; -.
DR Proteomes; UP000008720; Chromosome.
DR GO; GO:0003852; F:2-isopropylmalate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd07940; DRE_TIM_IPMS; 1.
DR Gene3D; 1.10.238.260; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:ADR21634.1};
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Pyruvate {ECO:0000313|EMBL:ADR21634.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008720};
KW Transferase {ECO:0000256|RuleBase:RU003523, ECO:0000313|EMBL:ADR21634.1}.
FT DOMAIN 5..266
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 386 AA; 42030 MW; 721D86C79EFAEB6F CRC64;
MARRIAIFDT TLRDGEQVPG CGLTKHQKLK IAKELEALGV DVIESGFPIS SPGDFESVRL
LSKEIKNSSI CALSRAVKND IETAARALEG AARPRIHTGL GTSDQHVFTK LNFTREQVLE
KAHECVTHAR SFVDEVEFYA EDAGRTSNEF LAQVIEVAVA AGAKVVNIPD TTGFCLPEEY
GAKIKYLVDN VKGIENATIS AHCHNDLGLA TANSIAAIKN GAGQIECTIN GIGERAGNTS
LEEVVMVMKK HPELALDTGI NTQLLFPISQ MVAETMCMPV QANKAVVGSN AFSHSSGIHQ
DGVIKNRDNY EIIDPYEVGV NKSSIILTAR SGRAALNFRL IELGVHLGKE ELEETYQQFC
ELADRINVVE DKDLKHLVKD HQVVVK
//
