ID E4TVF6_MARTH Unreviewed; 611 AA.
AC E4TVF6;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:ADR20088.1};
GN OrderedLocusNames=Ftrac_0074 {ECO:0000313|EMBL:ADR20088.1};
OS Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408
OS / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Marivirgaceae; Marivirga.
OX NCBI_TaxID=643867 {ECO:0000313|EMBL:ADR20088.1, ECO:0000313|Proteomes:UP000008720};
RN [1] {ECO:0000313|EMBL:ADR20088.1, ECO:0000313|Proteomes:UP000008720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 /
RC H-43 {ECO:0000313|Proteomes:UP000008720};
RX PubMed=21677852; DOI=10.4056/sigs.1623941;
RA Pagani I., Chertkov O., Lapidus A., Lucas S., Del Rio T.G., Tice H.,
RA Copeland A., Cheng J.F., Nolan M., Saunders E., Pitluck S., Held B.,
RA Goodwin L., Liolios K., Ovchinikova G., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Jeffries C.D., Detter J.C.,
RA Han C., Tapia R., Ngatchou-Djao O.D., Rohde M., Goker M., Spring S.,
RA Sikorski J., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Marivirga tractuosa type strain (H-43).";
RL Stand. Genomic Sci. 4:154-162(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002349; ADR20088.1; -; Genomic_DNA.
DR RefSeq; WP_013452239.1; NC_014759.1.
DR AlphaFoldDB; E4TVF6; -.
DR STRING; 643867.Ftrac_0074; -.
DR KEGG; mtt:Ftrac_0074; -.
DR eggNOG; COG0025; Bacteria.
DR eggNOG; COG0569; Bacteria.
DR HOGENOM; CLU_005912_10_1_10; -.
DR OrthoDB; 570124at2; -.
DR Proteomes; UP000008720; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008720};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..399
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 414..501
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02254"
SQ SEQUENCE 611 AA; 67369 MW; BDFEED261FD4A6ED CRC64;
MIELASILVL GVFAQWLAWK IKQPAILPLI LIGLVVGPFS TFFTPEGSKL IDGDQIFSGD
LLFSFVSLSV GVILFEGGLT LNLKEVRTVA STVRNLLIVG VLITFVGGTI AAVAILDLSL
SMALLFGGLI IVSGPTVVLP ILRNVRPNAK VNTILKWEGI LIDPLGALIA VLVYEFIKSS
SNGEYYTVEA LKDFFTTISV GFFIGGFGAV LIWYIISKNK IPDYLRNVIT LGTVILVFSV
SDLLQKEAGL LATTIMGIVL ANMKLDDFKK ILSFKEDISL ILVTLLFILL SSRIDIAQIE
QLGTRSLLLF AVVIFILRPL GVWLSSIGST LRWQEKLFVA WIGPRGIVAA AVASLFSLDL
LSSDTTSAAL KSEAELLLPL VFLVIVGTVV IQGTSAKYVG KWLGVLRKEP QGVLFVGANE
IAKKLALFLK KEGFYVLLAD TAKHNVNEAR KLNLQVYEGN ILSEEIFEEV DLSQIGKMMA
VTSNSGINSL ALSWFDNELG MENTYRIVSK EEAENENLPL PKNVLFKSRL DYLSLNHLLR
QNSEISEVKF YGESEYEEFL EEKGKTIIPL FIITSEKKLH IISGYPEEVG KDDRLIFLKN
KNYNMSSNEN E
//
