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Database: UniProt
Entry: E4U7K4_OCEP5
LinkDB: E4U7K4_OCEP5
Original site: E4U7K4_OCEP5 
ID   E4U7K4_OCEP5            Unreviewed;       345 AA.
AC   E4U7K4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=L-threonine 3-dehydrogenase {ECO:0000313|EMBL:ADR36453.1};
DE            EC=1.1.1.103 {ECO:0000313|EMBL:ADR36453.1};
GN   OrderedLocusNames=Ocepr_0996 {ECO:0000313|EMBL:ADR36453.1};
OS   Oceanithermus profundus (strain DSM 14977 / NBRC 100410 / VKM B-2274 /
OS   506).
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Oceanithermus.
OX   NCBI_TaxID=670487 {ECO:0000313|EMBL:ADR36453.1, ECO:0000313|Proteomes:UP000008722};
RN   [1] {ECO:0000313|Proteomes:UP000008722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14977 / NBRC 100410 / VKM B-2274 / 506
RC   {ECO:0000313|Proteomes:UP000008722};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Zhang X., Brettin T.,
RA   Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Faehnrich R.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete sequence of chromosome of Oceanithermus profundus DSM
RT   14977.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADR36453.1, ECO:0000313|Proteomes:UP000008722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14977 / NBRC 100410 / VKM B-2274 / 506
RC   {ECO:0000313|Proteomes:UP000008722};
RX   PubMed=21677858; DOI=10.4056/sigs.1734292;
RA   Pati A., Zhang X., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H.,
RA   Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Pagani I., Ivanova N., Mavromatis K., Chen A., Palaniappan K., Hauser L.,
RA   Jeffries C.D., Brambilla E.M., Rohl A., Mwirichia R., Rohde M.,
RA   Tindall B.J., Sikorski J., Wirth R., Goker M., Woyke T., Detter J.C.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA   Klenk H.P., Land M.;
RT   "Complete genome sequence of Oceanithermus profundus type strain (506).";
RL   Stand. Genomic Sci. 4:210-220(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP002361; ADR36453.1; -; Genomic_DNA.
DR   RefSeq; WP_013457623.1; NC_014761.1.
DR   AlphaFoldDB; E4U7K4; -.
DR   STRING; 670487.Ocepr_0996; -.
DR   KEGG; opr:Ocepr_0996; -.
DR   eggNOG; COG1063; Bacteria.
DR   HOGENOM; CLU_026673_11_0_0; -.
DR   OMA; LKGVFHN; -.
DR   OrthoDB; 9792162at2; -.
DR   Proteomes; UP000008722; Chromosome.
DR   GO; GO:0008743; F:L-threonine 3-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd05281; TDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR   PANTHER; PTHR43401:SF2; L-THREONINE 3-DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ADR36453.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008722};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          12..341
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   345 AA;  37164 MW;  2506D13B313FF314 CRC64;
     MKALVKETPA PGLTLREVDV REPGPGEILV KIRAASICGT DLHIWRWDHW AAGRLRPPVI
     TGHEFAGVVE AVGPGVATPR VGDHVSLESH IVCHTCYQCR TGKGHICQNT RILGVDTDGG
     FAEYATVPAE NAWVNPPDLP WEIAAVLEPF GNAVHTVYSG VGVEGRTVLV TGAGPIGLMA
     IAVARASGAT LVVATDLQPY RLEFARRMGA DRVVNVREED PVEVVRELTG GQGVEVLLEF
     SGSERAIHQG LQALMPGGEA RILGIPSDPI RFDLAGELVM RGITAVGIAG RRLYETWYQG
     SGLIYSGRVD LEPLITHRFA MADYREAFEL LERGEGVKAV LYPDA
//
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