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Database: UniProt
Entry: E4UHR5_9INFA
LinkDB: E4UHR5_9INFA
Original site: E4UHR5_9INFA 
ID   E4UHR5_9INFA            Unreviewed;       718 AA.
AC   E4UHR5;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   09-JUL-2014, sequence version 2.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
DE   Flags: Fragment;
GN   Name=PB1 {ECO:0000313|EMBL:ADT64882.2};
OS   Influenza A virus (A/duck/Victoria/30a/1981(H12N7)).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC   Alphainfluenzavirus influenzae; Influenza A virus.
OX   NCBI_TaxID=575457 {ECO:0000313|EMBL:ADT64882.2};
RN   [1] {ECO:0000313|EMBL:ADT64882.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/duck/Victoria/30a/1981 {ECO:0000313|EMBL:ADT64882.2};
RA   Spiro D., Halpin R., Boyne A., Bera J., Ghedin E., Hostetler J.,
RA   Fedorova N., Kim M., Zaborsky J., Overton L., Djuric K., Sarmiento M.,
RA   Sitz J., Katzel D., Boyle D., Bao Y., Sanders R.D., Dernovoy D.,
RA   Kiryutin B., Lipman D.J., Tatusova T.;
RT   "The NIAID Influenza Genome Sequencing Project.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADT64882.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/duck/Victoria/30a/1981 {ECO:0000313|EMBL:ADT64882.2};
RG   The NIAID Influenza Genome Sequencing Consortium;
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC       replication and transcription of virus RNA segments. The transcription
CC       of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC       methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC       by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC       transcription of viral mRNAs. During virus replication, PB1 initiates
CC       RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC       serves as a template for the production of more vRNAs.
CC       {ECO:0000256|ARBA:ARBA00002148}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC       {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CY077699; ADT64882.2; -; Viral_cRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.140.720; -; 1.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   4: Predicted;
KW   Eukaryotic host gene expression shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00023247};
KW   Eukaryotic host transcription shutoff by virus
KW   {ECO:0000256|ARBA:ARBA00022731};
KW   Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW   Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW   Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Inhibition of host RNA polymerase II by virus
KW   {ECO:0000256|ARBA:ARBA00023103};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU004330};
KW   Transferase {ECO:0000256|ARBA:ARBA00022484, ECO:0000256|RuleBase:RU004330};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW   Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT   DOMAIN          281..478
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50525"
FT   REGION          47..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADT64882.2"
FT   NON_TER         718
FT                   /evidence="ECO:0000313|EMBL:ADT64882.2"
SQ   SEQUENCE   718 AA;  81537 MW;  E18E1E65E7977BF4 CRC64;
     TLLFLKVPAQ NAISTTFPYT GDPPYSHGTG TGYTMDTVNR THQYSEKGKW TTNTETGAPQ
     LNPIDGPLPE DNEPSGYAQT DCVLEAMAFL EESHPGIFEN SCLETMEVVQ QTRVDKLTQG
     RQTYDWTLNR NQPAATALAN TIEVFRSNGM TANESGRLID FLKDVMESMD KEEMEVVTHF
     QRKRRVRDNM TKKMITQRTI GKKKHKLNRK SYLIRGLTLN TMTKDAERGK LKRRAIATPG
     MQIRGFVYFV ETLARSICEK LEQSGLPVGG NEKKAKLANV VRKMMTNSHD TELSFTITGD
     NTKWNENQNP RMFLAMITYI TRNQPEWFRN VLSIAPIMFS NKMARLGKGY MFESKSMKLR
     TQIPAEMLAS IDLKYFNEAT KKKIEKIRPL LIDGTASLSP GMMMGMFNML STVLGVSILN
     LGQKKYTKTT YWWDGLQSSD DFALIVNAPN HEGIQAGVDR FYRTCKLVGI NMSKKKSYIN
     RTGTFEFTSF FYRYGFVANF SMELPSFGVS GINESADMSI GVTVIKNNMI NNDLGPATAQ
     MALQLFIKDY RYTYRCHRGD TQIQTRRSFE LRKLWEQTRS KAGLLVSDGG PNLYNIRNLH
     IPEVCLKXXX XXXXXXXXXX XXXXXXXXXX XXXXXNNAVV MPAHGPAKSM EYDAVATTHS
     WIPKRNRSIL NTSQRGILED EQMYQKCCNL FEKFFPSSSY RRPVGISSMV EAMVSRAR
//
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