ID E4UHR5_9INFA Unreviewed; 718 AA.
AC E4UHR5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 2.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:ADT64882.2};
OS Influenza A virus (A/duck/Victoria/30a/1981(H12N7)).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC Alphainfluenzavirus influenzae; Influenza A virus.
OX NCBI_TaxID=575457 {ECO:0000313|EMBL:ADT64882.2};
RN [1] {ECO:0000313|EMBL:ADT64882.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/duck/Victoria/30a/1981 {ECO:0000313|EMBL:ADT64882.2};
RA Spiro D., Halpin R., Boyne A., Bera J., Ghedin E., Hostetler J.,
RA Fedorova N., Kim M., Zaborsky J., Overton L., Djuric K., Sarmiento M.,
RA Sitz J., Katzel D., Boyle D., Bao Y., Sanders R.D., Dernovoy D.,
RA Kiryutin B., Lipman D.J., Tatusova T.;
RT "The NIAID Influenza Genome Sequencing Project.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADT64882.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/duck/Victoria/30a/1981 {ECO:0000313|EMBL:ADT64882.2};
RG The NIAID Influenza Genome Sequencing Consortium;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-dependent RNA polymerase which is responsible for
CC replication and transcription of virus RNA segments. The transcription
CC of viral mRNAs occurs by a unique mechanism called cap-snatching. 5'
CC methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides
CC by PA. In turn, these short capped RNAs are used as primers by PB1 for
CC transcription of viral mRNAs. During virus replication, PB1 initiates
CC RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn
CC serves as a template for the production of more vRNAs.
CC {ECO:0000256|ARBA:ARBA00002148}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CY077699; ADT64882.2; -; Viral_cRNA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.720; -; 1.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
DR PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 4: Predicted;
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host transcription shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022731};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host RNA polymerase II by virus
KW {ECO:0000256|ARBA:ARBA00023103};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU004330};
KW Transferase {ECO:0000256|ARBA:ARBA00022484, ECO:0000256|RuleBase:RU004330};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Viral transcription {ECO:0000256|ARBA:ARBA00023314}.
FT DOMAIN 281..478
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
FT REGION 47..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADT64882.2"
FT NON_TER 718
FT /evidence="ECO:0000313|EMBL:ADT64882.2"
SQ SEQUENCE 718 AA; 81537 MW; E18E1E65E7977BF4 CRC64;
TLLFLKVPAQ NAISTTFPYT GDPPYSHGTG TGYTMDTVNR THQYSEKGKW TTNTETGAPQ
LNPIDGPLPE DNEPSGYAQT DCVLEAMAFL EESHPGIFEN SCLETMEVVQ QTRVDKLTQG
RQTYDWTLNR NQPAATALAN TIEVFRSNGM TANESGRLID FLKDVMESMD KEEMEVVTHF
QRKRRVRDNM TKKMITQRTI GKKKHKLNRK SYLIRGLTLN TMTKDAERGK LKRRAIATPG
MQIRGFVYFV ETLARSICEK LEQSGLPVGG NEKKAKLANV VRKMMTNSHD TELSFTITGD
NTKWNENQNP RMFLAMITYI TRNQPEWFRN VLSIAPIMFS NKMARLGKGY MFESKSMKLR
TQIPAEMLAS IDLKYFNEAT KKKIEKIRPL LIDGTASLSP GMMMGMFNML STVLGVSILN
LGQKKYTKTT YWWDGLQSSD DFALIVNAPN HEGIQAGVDR FYRTCKLVGI NMSKKKSYIN
RTGTFEFTSF FYRYGFVANF SMELPSFGVS GINESADMSI GVTVIKNNMI NNDLGPATAQ
MALQLFIKDY RYTYRCHRGD TQIQTRRSFE LRKLWEQTRS KAGLLVSDGG PNLYNIRNLH
IPEVCLKXXX XXXXXXXXXX XXXXXXXXXX XXXXXNNAVV MPAHGPAKSM EYDAVATTHS
WIPKRNRSIL NTSQRGILED EQMYQKCCNL FEKFFPSSSY RRPVGISSMV EAMVSRAR
//