ID E4UVK6_ARTGP Unreviewed; 852 AA.
AC E4UVK6;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Beta-hexosaminidase {ECO:0000313|EMBL:EFR02333.1};
GN ORFNames=MGYG_05331 {ECO:0000313|EMBL:EFR02333.1};
OS Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS gypseum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX NCBI_TaxID=535722 {ECO:0000313|Proteomes:UP000002669};
RN [1] {ECO:0000313|Proteomes:UP000002669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4604 / CBS 118893 {ECO:0000313|Proteomes:UP000002669};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC {ECO:0000256|ARBA:ARBA00005336}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS989825; EFR02333.1; -; Genomic_DNA.
DR RefSeq; XP_003172744.1; XM_003172696.1.
DR AlphaFoldDB; E4UVK6; -.
DR STRING; 535722.E4UVK6; -.
DR GeneID; 10028020; -.
DR VEuPathDB; FungiDB:MGYG_05331; -.
DR eggNOG; ENOG502R6JK; Eukaryota.
DR HOGENOM; CLU_008392_3_1_1; -.
DR InParanoid; E4UVK6; -.
DR OMA; MICHTFD; -.
DR OrthoDB; 2441209at2759; -.
DR Proteomes; UP000002669; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd04301; NAT_SF; 2.
DR Gene3D; 3.40.630.30; -; 2.
DR Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR30480:SF13; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR30480; BETA-HEXOSAMINIDASE-RELATED; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR Pfam; PF13508; Acetyltransf_7; 1.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
DR PROSITE; PS51186; GNAT; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002669};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 535..690
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 702..852
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
SQ SEQUENCE 852 AA; 94108 MW; 1D654493A6798BCA CRC64;
MSEEEIRRKL GQLFIVGFDG LTANEGIKSL IKAPFYIGNV ILFRRNVGDA EQLITLTSEL
QRTARDAGHT RPLFIAIDQE NGWVSQIKPP IAAQLPGSMA LGATGSTEDA IRVARATGEL
LYALGINMNY APVCDVNSEP ANPVIGVRSP GDDGVSVGRI ASAFAKGLRE EKVVPCVKHF
PGHGDTMVDS HYGLPVVNRS IEELEACELI PFRRTTAENV ESVMTSHIVL PALEESNLPM
TLSKSCVQFL RERLQYDGLL VSDCLEMEAI RAHYGSEKGA AMAIAAGVDC AMVCHTLKAQ
MGAYNEVYEA FKHGVITSEG VAKSVARVTA LKDRFVSWEL VSSKRTPELL AELRLAHEKL
AADVYARSVT LVRDTQNAIP IKPDQKVVYA YFALVGGFSG VPHTVPYLQS QFGKMIMEHH
SNMVECPIRQ DTSLEEDEEA KAKISDADVV ILVTKDAKMS GSQVELTRLI ERLSKKLIVV
AMSVPYDFLE DKELVKTYLT IYEPTPEAFL PAVKIILGDL KPKGKLPVSA KLRQIPIEPF
NAGRDLARVI KLWHQLLPRY AVPSATLSHV LTRPNGAHLV SRFEDEIVGF VATYVNEDRP
TTFIPVVLVD SGHQGKGVGT AMIEHARIYL RKRYPTSSVT IGSSFPRFWP GVPTDISKQA
QDFFIHRGFC PERRPSARDY TADLLSYEAP KGILERAEKA GVIFAPWSKE KYGQCMEKQR
KLFGKDAVWM GAYEGLAQTG RYDQVMVATD SSTGEQIGWT LMQELGIGMT QELAMQPLVG
IKSGQIGCVG VAPEARNKGV GLALITHAAL DLKRRGMEHV FIDWSNHVNW YERAGFKVWG
EYRTMVLHEL AK
//
