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Database: UniProt
Entry: E4WS79_OIKDI
LinkDB: E4WS79_OIKDI
Original site: E4WS79_OIKDI 
ID   E4WS79_OIKDI            Unreviewed;       845 AA.
AC   E4WS79;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   16-MAR-2016, entry version 15.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=GSOID_T00000613001 {ECO:0000313|EMBL:CBY20612.1};
OS   Oikopleura dioica (Tunicate).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Oikopleuridae;
OC   Oikopleura.
OX   NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY20612.1, ECO:0000313|Proteomes:UP000001307};
RN   [1] {ECO:0000313|EMBL:CBY20612.1, ECO:0000313|Proteomes:UP000001307}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21097902; DOI=10.1126/science.1194167;
RA   Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA   Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA   Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M.,
RA   Cross I., Yadetie F., Muffato M., Louis A., Butcher S.,
RA   Tsagkogeorga G., Konrad A., Singh S., Jensen M.F., Cong E.H.,
RA   Eikeseth-Otteraa H., Noel B., Anthouard V., Porcel B.M.,
RA   Kachouri-Lafond R., Nishino A., Ugolini M., Chourrout P., Nishida H.,
RA   Aasland R., Huzurbazar S., Westhof E., Delsuc F., Lehrach H.,
RA   Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA   Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O.,
RA   Du Pasquier L., Boudinot P., Liberles D.A., Volff J.N., Philippe H.,
RA   Lenhard B., Roest Crollius H., Wincker P., Chourrout D.;
RT   "Plasticity of animal genome architecture unmasked by rapid evolution
RT   of a pelagic tunicate.";
RL   Science 330:1381-1385(2010).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; FN653015; CBY20612.1; -; Genomic_DNA.
DR   InParanoid; E4WS79; -.
DR   Proteomes; UP000001307; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001307};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    400    424       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    463       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    554       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    594       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    645    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    749    767       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    787    810       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   845 AA;  96574 MW;  115D34B55CF44BDB CRC64;
     MSSILRSEEM CLAQLFLQSD AAYSCISELG ELGLVQFRDL NADVSAFQRK FVPELRRCDE
     MERKLRYLDE ELQKAEIPVI DNNESPEAPL PKETLPLEND LEQLEKQMRE VSQNQEQLNK
     NFLELTELKH VLRKTQSFFE EAQDFAAQRP AWQSSGHEEM SSNPLRLGFI AGVIVRERIP
     LFERILWRAC RGNVFLRHIE IDAPLKDPVT GHEVHKSVFI IFYQGEQLRS RTKKICESLK
     ASIYPCPENP QERREVAMNV MTRIQDLDQV LKTTNEQRNR ILAQVARNIR VWFIKVRKVT
     AIYHSLNMFS VDLGQRCLIG EIWCPVSEID RIQLALRRGT ERCGASVNSI LHRIKTNMTP
     PTYFRTDKFT TGFQAIIEAY GVADYREINP AFFTIISFPF LYGVMFGDMG HGIIMALVAA
     FMCWKETEIG RKKDLNEMIA ILFHGRYIIL LMGLFSTYAG FIYNDIFSKS LNIFGSYWTV
     SDQPGIEDWI KTAPAESTIQ LNPNFTSDGP YPYGMDPIWQ LSSNKIVFID SFKMKGSVIL
     GVTHMCFGLV LAYFNHRHFN DHVTIIWEWI PRCLFMGCIF VYLCLTIFIK WIFWDASTSG
     NAPSLLINLI GMFMLKTPTK EDNTWVYGSL NAEGEATAQG LVQKLLLLIA FASLPVMLLA
     KPYIKYKEWK DKRNRSTANF GGVRVEIEGN DDTEGILDGD ELARESGSDH QPQEEVEEFD
     VGGMMILQII HTIEFALGCI SHTASYLRLW ALSLAHAELS EVLWTMVLKM GLSMSSSGSV
     GAIMSYLVFW AFAALSVGIL ICMEGLSAFL HAMRLHWVEF NDKFYGGEGI AFKPFYFETI
     LSGEE
//
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