ID E4WXP1_OIKDI Unreviewed; 497 AA.
AC E4WXP1;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN ORFNames=GSOID_T00011680001 {ECO:0000313|EMBL:CBY22134.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY22134.1};
RN [1] {ECO:0000313|EMBL:CBY22134.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; FN653018; CBY22134.1; -; Genomic_DNA.
DR AlphaFoldDB; E4WXP1; -.
DR InParanoid; E4WXP1; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 21..192
FT /note="ECSIT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06239"
FT DOMAIN 226..323
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14784"
SQ SEQUENCE 497 AA; 57567 MW; E2D8BA5344DFB0C2 CRC64;
MDKSYANEME AYLADAEHSY IQEADKRAFY MAVELWKKEA GPGRQGHKDF VVMAIPTISQ
LGLSKDTKAY MTLLECWPDA NYVFAEKSPI YKQTTSQSTF FIEKFEWTSD ANLCKHLLRT
MERNGCLCTN EIYAKVTDLF GIYSDASVLA RQQMLFNKRL MERNPFPIDA PKDPTELAAA
TLRQASPGFD RQYHRFPMKQ RDGNWVRSEK SGEFFESHDS VIVSQSPEQL NNLQNHNQDE
PVLIEGPISI FMNGKATEIF VLRSENQVEK TAREKRNEKF DKKYTTVISN KEWFADFYGK
DLETGMELHG GKQRTMRAFG AQGVMDQMDK SVLELEATHE KRLIFPKEEE PIYEQIEYDL
SWKPIEDFSG DSIPELLKSG HLRSEEFADE VQLGRRTEAK VFCLAHIDCE QKLLPDAYST
WIRGIAETVE PKVQNFTVVL REDWTPEKSD HLTIDPSLGN RGYNQIEEVL ESEQYDEEFE
EEIRREQIEL LFGSKST
//
