ID E4X204_OIKDI Unreviewed; 500 AA.
AC E4X204;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=GSOID_T00015911001 {ECO:0000313|EMBL:CBY23471.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY23471.1};
RN [1] {ECO:0000313|EMBL:CBY23471.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
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DR EMBL; FN653021; CBY23471.1; -; Genomic_DNA.
DR AlphaFoldDB; E4X204; -.
DR InParanoid; E4X204; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF355; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT DOMAIN 243..470
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 500 AA; 56792 MW; D4CF05EFC2E55C37 CRC64;
MYGTLPKSTR SKTKYSKEEY ATMIVEKIIK DKNQETISSL LSCCQLYTSP LLIIRELRSV
FLASSPRFEK SKKAQIVQLN TSTVNYHTIR RPRKAPKPAA KNDELDQILS QIEELKLKLF
DPAEEAYSRD SGIASSIVSD DDLEYCTEAG HVTPLDLRSK IAEVVVAWIK KEPMVFVDDV
VFHVMRKFLD EIAAAKILTQ NTRALLDSSM KTNSRISTSF FCKITPLTNE PLSNLKNFDL
QKTLGPLAAH INYLDAMFYK NLSRDDVISQ LVQAGVRPRW NSYLNSMARL NSLVSIAILK
SPSPAEAAKM IDMFVILACC CRRAKNYNAT ITIITALLSK PIQRLSKTWT KVKELQNLAM
LKTLANPSNN FRSLRKELKS QKEVLAPYLT LVGKDVFWIA QGANERQNIH EVESRTKLLA
RSIPRPARRI PEPCETCRNG AKCKVMEALT TFSIMSDDAL YHLSYKMESP TNSFEKEEFR
SLKPKKKPVR SLRKLIQLLV
//
