ID E4X5A5_OIKDI Unreviewed; 490 AA.
AC E4X5A5;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Dynein regulatory complex protein 1 {ECO:0000256|ARBA:ARBA00013815};
DE AltName: Full=Coiled-coil domain-containing protein 164 {ECO:0000256|ARBA:ARBA00031554};
DE AltName: Full=Coiled-coil domain-containing protein 65 {ECO:0000256|ARBA:ARBA00041517};
DE AltName: Full=Dynein regulatory complex subunit 2 {ECO:0000256|ARBA:ARBA00040899};
GN ORFNames=GSOID_T00002337001 {ECO:0000313|EMBL:CBY18474.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY18474.1};
RN [1] {ECO:0000313|EMBL:CBY18474.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}. Cytoplasm, cytoskeleton,
CC flagellum basal body {ECO:0000256|ARBA:ARBA00037841}.
CC -!- SIMILARITY: Belongs to the DRC2 family.
CC {ECO:0000256|ARBA:ARBA00038424}.
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DR EMBL; FN653025; CBY18474.1; -; Genomic_DNA.
DR AlphaFoldDB; E4X5A5; -.
DR InParanoid; E4X5A5; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:InterPro.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:InterPro.
DR InterPro; IPR039505; DRC1/2_N.
DR InterPro; IPR039750; DRC1/DRC2.
DR InterPro; IPR029440; DRC1_C.
DR PANTHER; PTHR21625:SF0; DYNEIN REGULATORY COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR21625; NYD-SP28 PROTEIN; 1.
DR Pfam; PF14772; NYD-SP28; 1.
DR Pfam; PF14775; NYD-SP28_assoc; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT DOMAIN 20..119
FT /note="Dynein regulatory complex protein 1/2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14772"
FT DOMAIN 392..435
FT /note="Dynein regulatory complex protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14775"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 254..299
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 369..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 57512 MW; 2C3906E9DD18EA8F CRC64;
MPKKAPKMSE EERLQWEADK AAAEADAERA EKEMILNYMK DKLAREEKYS RLNNKKLIEK
WRSIMRQSKS AELKKELQIL SHTFERIMDR KDAVTQQLAR DLEESEEQSR IATRAHQRNL
QKLIEIQNAA VNDQQDRYDT EINMETSNFN ETAQQYVDKT QKSDHDFDTM MCALEQTHID
RTSKLKQEFQ SLRDEIKNNT QDEKHALRIS LEAAVEKLFK MFQQAQKDYD NSTLERRKEF
EKLQAKDAKS SAEIELQMNK LAKIQENINI VKQKMVNNTK EYEEKHAGLK ENKDHLQTHF
RVLRTEMGKQ RNKERELLTK LTLASEEALK RQKNIDQKAS KILKIGEMCR KLETEEEQVL
PFGIVPPTPR TEEEDKALED GKPNPVTEIV KDYEQLEGFW RRYNKVKLDR LALEAEKVSL
EEENMTLRSV LKQYLDGVSV NSETLKEPNP LFVVNQRTNV KFEVPQVDPR VKKPVVTVVE
AAHAVKHTHH
//
