ID E4XC70_OIKDI Unreviewed; 761 AA.
AC E4XC70;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=GSOID_T00007724001 {ECO:0000313|EMBL:CBY09195.1};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765 {ECO:0000313|EMBL:CBY09195.1};
RN [1] {ECO:0000313|EMBL:CBY09195.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21097902; DOI=10.1126/science.1194167;
RA Denoeud F., Henriet S., Mungpakdee S., Aury J.M., Da Silva C.,
RA Brinkmann H., Mikhaleva J., Olsen L.C., Jubin C., Canestro C.,
RA Bouquet J.M., Danks G., Poulain J., Campsteijn C., Adamski M., Cross I.,
RA Yadetie F., Muffato M., Louis A., Butcher S., Tsagkogeorga G., Konrad A.,
RA Singh S., Jensen M.F., Cong E.H., Eikeseth-Otteraa H., Noel B.,
RA Anthouard V., Porcel B.M., Kachouri-Lafond R., Nishino A., Ugolini M.,
RA Chourrout P., Nishida H., Aasland R., Huzurbazar S., Westhof E., Delsuc F.,
RA Lehrach H., Reinhardt R., Weissenbach J., Roy S.W., Artiguenave F.,
RA Postlethwait J.H., Manak J.R., Thompson E.M., Jaillon O., Du Pasquier L.,
RA Boudinot P., Liberles D.A., Volff J.N., Philippe H., Lenhard B.,
RA Roest Crollius H., Wincker P., Chourrout D.;
RT "Plasticity of animal genome architecture unmasked by rapid evolution of a
RT pelagic tunicate.";
RL Science 330:1381-1385(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN653035; CBY09195.1; -; Genomic_DNA.
DR AlphaFoldDB; E4XC70; -.
DR InParanoid; E4XC70; -.
DR Proteomes; UP000001307; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR23257:SF780; AT08303P; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001307}.
FT DOMAIN 435..747
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 229..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 86488 MW; 7C4520267238162B CRC64;
MSIIHEVDKE KKLIMHNGDG IGRHEKDENL IEITKTLLEI KIKHLRKIRE LTEEGKLNDI
VDDVHETEKD ILETVAVLIV LKKRFSVKTQ TKLLPTYLLQ LASFSLRDWC VALGISEKGG
AKIVQKFETD ILGFLELSNW GRSGVGSHAE LSEESFRKQL TLIKGISEED VRRLWHANYN
LAHLIDALEQ SHESCIFTAV QQLTGKNEYD ATHFWSSWRH VDRRMSQVES GDRRYSSESS
EASAHSPGIL DTSSSSVFSP LPKAKSPEQN HSRFGRDSGL GDSQLKSFSF PKRLRKSQDT
SRLSPSTTRI SENSLIDPYA EVSAKRKDGV FCYPDRPDAQ STPFHKNPKL SCNRSPVPFK
IAELSLNDSM GEPSCLASYD AFSYTETTDS VEELKNPPRT RNRSQEVQDR TSAFRNKKTA
FKSMLVDWEV HFDDLILERE LPGGRFGTKC HICKWHGKCV IRVAKVDLKP ENPNVQAFKQ
ELHHFKKTRH DNVELFLGAC LTPPNLAILT RYYQGPRLDK KIKEESLSLD NARLLADHII
NGLKYLHAKD ILHKDLRPAN IMYDLVGKAV IKGLGLATVS ALTGVGSIRN NPETEKYYID
VPTDWIHRLS PELATIDLEK CQNSSIIPKL NYSKKSDIYA FGVLWAELMQ AVHRSSQPAP
LTLRRENDFN SSRRVEKSEL RIDLNTPPTD NFESKLFNAG LGSKIEVPDP IQDQARCLIN
RCVERSPTNR PDCEWIAERL DKVQPNAGRL TRRCTYTAHR S
//
